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Email ：PharmaSources@imsinoexpo.com
Whatsapp ：+86-13621645194
Main Sales Markets: North America,Central/South America,Western Europe,Eastern Europe,Australasia,Asia,Middle East
Monthly Production Capacity: 1000kg
Packaging Information: 25kg/drum 1kg/bottle
Delivery Lead Time: 7 days after payment
Sample Provided: yes
Payment Terms: L/L
Product Information
Product name
Candesartan cilexetil
CAS No.
145040-37-5
Molecular Formula
C33H34N6O6
Molecular Weight
610.66
Quality Standard
99% up, Medicine Grade
Appearance
White powder
COA of Candesartan cilexetil
Items
Specifications
Results
Appearance
A white or almost white powder
White powder
Identification-IR
Complies with the reference spectrum
Complies
Identification- UV
Maximal absorptions at 254nm,
minimum absorption at 242nm
Complies
Water
≤ 0.3%
0.19%
Residual solvents
Methanol
≤ 3000ppm
Not found
Ethanol
≤ 5000ppm
Not found
Ethyl ether
≤ 5000ppm
68ppm
Acetone
≤ 5000ppm
482ppm
Ethyl acetate
≤ 5000ppm
Not found
Dichloromethane
≤ 600ppm
Not found
Dimethylformamide
≤ 880ppm
Not found
Related substances
Impurity A
≤ 0.15%
< 0.05%
Impurity B
≤ 0.3%
< 0.05%
Impurity F
≤ 0.2%
< 0.05%
Impurity G
≤ 0.2%
< 0.05%
Impurity H
≤ 0.15%
Not found
Other individual impurity
≤ 0.10%
0.04%
Total impurities
≤ 0.6%
0.21%
Sulfated ash
≤ 0.1%
0.06%
Heavy metals
≤ 10ppm
<10ppm
Assay (Dried substance)
99.0~101.0%
99.8%
Conclusion:
The product complies with EP 9.0
Usage
Function of Candesartan cilexetil Candesartan cilexetil is an angiotensin II receptor antagonist, also referred to as an ARB drug for short. Candesartan cilexetil is currently recognized as a first-line treatment for hypertension. Candesartan cilexetil tablets can bind to the AT1 receptor of vascular smooth muscle, thereby antagonizing the vasoconstriction effect of angiotensin II and reducing the resistance of peripheral blood vessels.
Among the similar ARB drugs, candesartan cilexetil has the strongest receptor affinity, so it has a longer binding time, so it is a long-acting angiotensin II receptor antagonist, which can be administered once every 24 hours. Can play a stable, long-lasting and effective antihypertensive effect. Not only that, studies have found that candesartan cilexetil can also improve fibrinolytic activity, promote the recovery of vascular endothelial function, and help protect cardiovascular and cerebrovascular other than blood pressure.
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