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99% up by HPLC Ademetionine 1,4-Butanedisulfonate SAM 101020-79-5
Category:Active Pharmaceutical Ingredients > Other Active Pharmaceutical Ingredients Product Name:99% up by HPLC Ademetionine 1,4-Butanedisulfonate SAM 101020-79-5 CAS No.:101020-79-5 Standard:USP, BP, EP, JP, In-house Standards Price(USD):Negotiable Company:Sinoway Industrial Co.Ltd.
Main Sales Markets: North America,Central/South America,Western Europe,Eastern Europe,Australasia,Asia,Middle East
Monthly Production Capacity: 1000kg
Packaging Information: 25kg/drum 1kg/bottle
Delivery Lead Time: 7 days after payment
Sample Provided: yes
Payment Terms: L/L
Product Information
Product name
Ademetionine 1,4-butanedisulfonate / SAM / SAMe
CAS No.
101020-79-5
Molecular Formula
C23H41N6O17S5-
Molecular Weight
833.91
Quality Standard
99% up by HPLC
Appearance
White powder
COA of Ademetionine 1,4-butanedisulfonate
ITEMS
STANDARDS
RESULTS
Appearance
A white or almost white powder
White powder
Solubility
Freely soluble in water, practically insoluble in ethanol and in acetone.
Conforms
Identification
1. The gas it produced can make wet potassium iodate test pater show blue.
Conforms
2. UV: it has absorption maximum at the 258nm
3. HPLC: the retention time of the principal peak in the chromatogram obtained with test solution is in accordance with that of the reference.
pH
2.1~2.5
2.4
Clarity and color of solution
Color: ≤Y3# or YG3#
Conforms
A solution should be clear.
Isomers
(S,S-Isomer) ≥70%
74.00%
Related substances
Adenine≤0.4%
0.05%
S-Adenosyl-L-Homocysteine≤0.4%
0.09%
Methylthioadenosine≤2.0%
0.43%
Decarboxylation adenosine methionine≤1.2%
1.00%
The other unknown impurities≤1.0%
0.05%
Total of impurities≤4.0%
1.80%
Water
≤6.0%
2.40%
Residual solvents
Ethyl acetate≤5000ppm
Conforms
Microbial limit tests
Bacteria≤1000cfu/g
Conforms
Bacterial endotoxins
≤0.438 EU/mg
Conforms
Content (dried basis)
Butanedisuphonic acid: 46.0~51.0%
47.20%
Adenosine methionine: 48.0~53.0%
52.20%
Total≥96.0%
99.40%
Conclusion
Conforms to enterprise standard
Usage
Function of Ademetionine 1,4-butanedisulfonate
Ademetionine 1,4-butanedisulfonate (SAM / SAMe) is a physiologically active molecule commonly found in human tissues and body fluids. It acts as a methyl donor (transmethylation) and a precursor of physiological sulfhydryl compounds (such as cysteine, taurine, glutathione, coenzyme A, etc.) (transsulfation) , participates important functions of biochemical reaction in the body.
The multiple mechanisms of adenosylmethionine are mainly reflected in the following aspects:
1. Transmethylation: Improve liver cell membrane fluidity, enhance Na+-K+-ATPase activity, promote bile secretion and operation, and participate in neurotransmitter synthesis, which can improve patient mood.
2. Transsulfide group: generate endogenous antidote, such as cysteine, glutathione, taurine, etc., play detoxification and antioxidant effects, and reduce liver cell damage.
3. Transformation of propylamino group: Synthesize biological polyamines, participate in metabolism in the body, regulate the regeneration and proliferation of liver cells, and accelerate the repair of liver function.
Indication of Ademetionine 1,4-butanedisulfonate:
Suitable for intrahepatic cholestasis before and after cirrhosis.
Suitable for intrahepatic cholestasis during pregnancy.
Twenty years of qualification
Audited Supplier
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