99% up 6-Benzofurancarboxylic Acid 77095-51-3

Name: 99% up 6-Benzofurancarboxylic Acid 77095-51-3
Availability: 99-up-6-benzofurancarboxylic-acid-77095-277538.html

Category:Intermediates > Pharmaceutical Intermediates
Product Name:99% up 6-Benzofurancarboxylic Acid 77095-51-3
CAS No.:77095-51-3
Standard:USP, BP, EP, JP, In-house Standards
Price(USD):Negotiable
Company:Sinoway Industrial Co.Ltd.

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Basic Info

Grade: Pharmaceutical Grade

Factory Location: Xiamen, Fujian

Main Sales Markets: North America,Central/South America,Western Europe,Eastern Europe,Australasia,Asia,Middle East
Monthly Production Capacity: 1000kg

Packaging Information: 1kg/bottle
Delivery Lead Time: 7 days after payment

Sample Provided: yes

Payment Terms: L/L

Product Information

Product name	6-Benzofurancarboxylic acid
Systematic name	1-benzofuran-6-carboxylic acid; Benzofuran-6-carboxylic acid; LIFI-009; Lifitegrast intermediate
CAS No.	77095-51-3
Molecular Formula	C9H6O3
Molecular Weight	162.145
Quality Standard	99% up
Appearance	White powder

Usage

6-Benzofurancarboxylic acid is one of the key intermediates of Lifitegrast.

Function of Lifitegrast

Lifitegrast is a leukocyte function antigen 1 antagonist used in the treatment of dry eye. Lifitegras can bind to leukocyte functional antigen 1 (LFA-1), preventing the binding of LFA-1 to its cognate ligand intercellular adhesion molecule-1 (ICAM-1). ICAM-1 is overexpressed in the corneal Chemicalbook membrane and conjunctival tissues of patients with dry eye, and LFA-1 binds to ICAM-1 to promote the formation of immune synapses, leading to activation of T cells and migration to target tissues. In vitro studies have shown that Lifitegrast can inhibit T cell adhesion to ICAM-1 and also inhibit the secretion of inflammatory cytokines in human peripheral blood mononuclear cells.

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