Basic Info
  • Grade: Pharmaceutical Grade

    Factory Location: Xiamen Fujian

    Main Sales Markets: North America,Central/South America,Western Europe,Eastern Europe,Australasia,Asia,Middle East,Africa

  • Monthly Production Capacity: 10ton/year

    Packaging Information: 25kg/drum; 5kg/bag, 1kg/bag

  • Delivery Lead Time: 7 days after payment

    Sample Provided: yes

    Payment Terms: L/L

    Product Information

     

    Product name

    Linaclotide

    CAS No.

    851199-59-2

    Molecular Formula

    C59H79N15O21S6

    Molecular Weight

    1526.736 g/mol

    Quality Standard

    98% up, Medicine Grade

    Appearance

    White powder

    Sequence

    H-Cys-Cys-Glu-Tyr-Cys-Cys-Asn-Pro-Ala-Cys-Thr-Gly-Cys-Tyr-OH cyclic(1-6),(2-10),(5-13)-tris(disulfide)

     

    COA of Linaclotide

     

    Test

    Specifications

    Appearance

    White or almost white crystalline powder

    Identity by HPLC

    The reaction is same with the reference substance

    Amino Acid Composition

    ±20% of theoretical

    Purity (HPLC)

    ≥ 98.0%

    Related Substance(By HPLC)

    Total Impurities(%)≤ 2.0%
    Largest Single Impurity(%)≤ 1.0%

    Acetate Content(By HPLC)

    ≤15%

    Water Content(By HPLC)

    ≤5.0%

    Bacterial Endotoxins

    ≤5IU/mg

     

    Usage

    Function of Linaclotide

     

    Linaclotide can bind to the guanylate cyclase C-type receptor (GC-C) in the intestinal tract after being taken orally into the human body to increase the intracellular and extracellular cyclic guanylic acid (cGMP) concentration and stimulate the secretion of intestinal juice , To accelerate the migration of the gastrointestinal tract, thereby increasing the frequency of bowel movements. Due to its unique mechanism of action, it is promising to become a therapeutic drug that can not only treat constipation, but also treat abdominal distension, abdominal pain and other clinical symptoms.

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