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Email ：PharmaSources@imsinoexpo.com
Whatsapp ：+86-13621645194
Main Sales Markets: North America,Central/South America,Western Europe,Eastern Europe,Australasia,Asia,Middle East
Monthly Production Capacity: 1000kg
Packaging Information: 25kg/drum 1kg/bottle
Delivery Lead Time: 7 days after payment
Sample Provided: yes
Payment Terms: L/L
Product Information
Product name
Irbesartan
CAS No.
138402-11-6
Molecular Formula
C25H28N6O
Molecular Weight
428.53
Quality Standard
98% up, USP/ EP
Appearance
White to almost white powder
COA of Irbesartan
ITEMS
STANDARDS
RESULTS
Appearance
White to off-white powder
White powder
Identification
Infrared absorption:
The IR spectrum is consistent with that obtained with the reference
Conforms
The retention time of the major peak in the chromatogram of the assay preparation corresponds to that in the chromatogram of the standard preparation, as obtained in the assay
Conforms
Water
NMT 0.5%
0.24%
Limit or Azide
NMT10ppm
Not detected
Heavy metals
NMT0.002%
Conforms
Related compounds
(HPLC)
Compound A NMT0.2%
0.01%
Any other impurity NMT0.1%
0.04%
Total impurity NMT0.5%
0.09
Residual solvents(GC)
Ethanol NMT 5000ppm
2307 ppm
Toluene NMT 890ppm
238 ppm
Dichloromethane NMT3000 ppm
Not detected
N,N-Dimethylformamide NMT880 ppm
Not detected
T-butyl Methyl Ether NMT 5000 ppm
Not detected
Assay
98.0—102.0%
99.2%
Conclusion
The analysis results show that this batch of irbesartan conforms to USP
Usage
Function of Irbesartan
Irbesartan is an angiotensin Ⅱ (Angiotensin Ⅱ, Ang Ⅱ) receptor inhibitor, can inhibit the conversion of Ang Ⅰ to Ang Ⅱ, can specifically antagonize the angiotensin converting enzyme 1 receptor (AT1), the antagonism of AT1 is greater than AT28500 Double, by selectively blocking the binding of AngⅡ and AT1 receptors, inhibiting vasoconstriction and the release of aldosterone, resulting in a hypotensive effect. This product does not inhibit angiotensin converting enzyme (ACE), renin, other hormone receptors, nor does it inhibit ion channels related to blood pressure regulation and sodium balance. It is mainly used for the treatment of essential hypertension and type 2 diabetic nephropathy with hypertension.
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