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Email ：PharmaSources@imsinoexpo.com
Whatsapp ：+86-13621645194
Main Sales Markets: North America,Central/South America,Western Europe,Eastern Europe,Australasia,Asia,Middle East
Monthly Production Capacity: 1000kg
Packaging Information: 25kg/drum 1kg/bottle
Delivery Lead Time: 7 days after payment
Sample Provided: yes
Payment Terms: L/L
Product Information
Product name
Sitagliptin Phosphate
CAS No.
654671-78-0/ 654671-77-9
Molecular Formula
C16H18F6N5O5P
Molecular Weight
505.31
Quality Standard
98.5% up by HPLC
Appearance
White powder
COA of Sitagliptin Phosphate
ITEMS
STANDARDS
RESULTS
Appearance
White or off-white crystalline powder
Complies
Identification
A. Sitagliptin phosphate in water display discriminate reaction of phosphate.
B. HPLC: RRT test solution is similar to RRT reference solution.
C. IR: Similar to Reference Substance
Complies
Complies
Complies
Related substance
XG-E ≤0.15%
N.D.
XG-F ≤0.15%
N.D.
XG-G ≤0.15%
N.D.
XG-H ≤0.15%
N.D.
XG-K ≤0.15%
N.D.
XG-L ≤0.15%
0.01%
XG-M ≤0.15%
N.D.
XG-N ≤0.15%
N.D.
Other individual impurity ≤0.10%
N.D.
Total impurities ≤0.5%
0.01%
Isomer
XG-A ≤0.15%
N.D.
Water
3.0%~4.5%
3.6%
Residual solvents
Isopropyl alcohol ≤0.5%
0.02%
Methyl tert-bytyl ether ≤0.5%
N.D.
Acetoacetate ≤0.5%
N.D.
Dimethylformamide ≤0.088%
N.D.
Heavy metals
≤ 10ppm
Complies
Assay
≥98.5% on anhydrous basis
100.3%
Conclusion
Conforms to enterprise standard
Usage
Function of Sitagliptin Phosphate
Sitagliptin phosphate belongs to the class of Oral antihyperglycemic agents. For patients with type II diabetes, after taking it, it can improve blood sugar by increasing the level of active insulin-stimulating hormone, which can reduce fasting blood sugar, and can also play a role in regulating the level of postprandial blood sugar, so that blood sugar can be controlled at a stable level. status.
1. Monotherapy:
Sitagliptin phosphate, in combination with diet and exercise, is used to improve glycemic control in patients with type II diabetes.
2. In combination with metformin:
When metformin hydrochloride alone has poor glycemic control, sitagliptin phosphate can be used in combination with metformin hydrochloride to improve glycemic control in patients with type II diabetes on the basis of diet and exercise.
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