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Email ：PharmaSources@imsinoexpo.com
Whatsapp ：+86-13621645194
Main Sales Markets: North America,Central/South America,Western Europe,Eastern Europe,Australasia,Asia,Middle East
Monthly Production Capacity: 1000kg
Packaging Information: 25kg/drum 1kg/bottle
Delivery Lead Time: 7 days after payment
Sample Provided: yes
Payment Terms: L/L
Product Information
Product name
Prednisolone
CAS No.
50-24-8
Molecular Formula
C21H28O5
Molecular Weight
360.444
Quality Standard
97% up by HPLC, EP8/USP38/BP2014
Appearance
White powder
COA of Prednisolone
Items
Specifications
Results
Appearance
White or almost white crystalline powder
White crystalline powder
Identification
A;B
Meets test
Specific rotation
+97°~+103°
+99°
Chromatogram purity
Any peak≤1.0%
Only one peak＞0.50%
Total≤2.0%
Epi-prednisolone＜0.05%
Hydrocortisone: 0.79%
11-Deoxypredmosolone＜0.05%
Other detected imputiry: RRT (0.81) 0.06%
Total: 0.85%
Loss on drying
≤0.5%
0.1%
Residue on ignition
Negligible
Negligible
Selenium
≤0.003%
＜0.003%
Residual solvents
Methanol≤700ppm
Methylene chloride≤600ppm
29ppm
507ppm
Assay
97.0~102.0%
(on dried substance)
99.0%
Conclusion
It conforms to USP38
Micronized
≤15μm＞80%;≤30μm＞98%
Usage
Function of Prednisolone
Prednisolone is an adrenal cortex hormone drug. Super-physiological glucocorticoids have a variety of pharmacological effects such as anti-inflammatory, anti-allergic and immune suppression.
1. Anti-inflammatory effects: glucocorticoids reduce and prevent tissue response to inflammation, thereby reducing the performance of inflammation.
2. Immunosuppressive effects: prevent or inhibit cell-mediated immune responses, delayed allergic reactions, reduce the number of T lymphocytes and monocyte eosinophils, reduce the binding ability of immunoglobulins and cell surface receptors, and inhibit interleukins Synthesis and release, thereby reducing the transformation of T cells to lymphoblasts, and reducing the expansion of the primary immune response.
3. Anti-toxic and anti-shock effects: Glucocorticoids can counteract the stimulating response of bacterial endotoxins to the body, reduce cell damage, and play a role in protecting the body.
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