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Main Sales Markets: North America,Central/South America,Western Europe,Eastern Europe,Australasia,Asia,Middle East
Monthly Production Capacity: 1000kg
Packaging Information: 25kg/drum 1kg/bottle
Delivery Lead Time: 7 days after payment
Sample Provided: yes
Payment Terms: L/L
Product Information
Product name
Atracurium Besylate
CAS No.
64228-81-5
Molecular Formula
C53H72N2O12.2(C6H5O3S)
Molecular Weight
257.60
Quality Standard
96% up by HPLC, GMP,USP
Appearance
White or almost white powder
COA of Atracurium Besylate
ITEMS
SPECIFICATION
RESULT
Appearance:
white or almost white powder,
slightly hygroscopic, ordorless
Confirms
Very solutable in acetonitrile or chloroform, Soluble in Water, very soluble and practically insolutable in ethyl ether
Confirms
Identification
(1) IR
Conforms
(2) HPLC
Conforms
Water
≤ 5.0%
0.6%
Residue on ignition
≤ 0.2%
0.1%
Methyl benzenesulfonate
≤ 0.1%
Undetected
Toluene
≤ 890ppm (ICH)
102ppm
Chromatographic purity
(1) Laudanosine: ≤ 0.5%
(2) Other individual impurities: ≤ 1.0%
(3) Total Impurities: ≤ 3.5%
0.01%
0.38%
1.3%
Isomer Ratio
Trans-Trans Isomer: 5%-6.5%
5.7%
Cis-Trans Isomer: 34.5%-38.5%
36%
Cis-Cis Isomer: 55%-60%
58.2%
Assay
96%-102%
(C65H82N2O18S2 on anhydrous basis)
100.2%
Residue Solvents
(1) Dichloromethane: ≤ 600ppm
(2) Acctonitrile: ≤ 410ppm
(3) Ethyl ether: ≤ 5000ppm
Undetected
Undetected
1739ppm
Result
Confirms to USP34
Usage
Function of Atracurium Besylate
Atracurium besylate is a skeletal muscle relaxant for general anesthesia, suitable for the treatment of muscle relaxation for endotracheal intubation and for muscle relaxation required for thoracic and abdominal surgery. Like most neuromuscular blocking agents, it can Causes the release of histamine, skin flushing, transient hypotension, and occasionally bronchospasm. Caution should be used in patients with myasthenia gravis, neuromuscular disease, and severe electrolyte disturbances, as it potentiates the effects of other non-depolarizing agents. People with severe cardiovascular disease are more sensitive to the transient hypotensive reaction of this product, so it is recommended to give slow intravenous injection in divided doses.
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