96%-102% CARMUSTINE 154-93-8

Name: 96%-102% CARMUSTINE 154-93-8
Availability: 96-102-carmustine-154-93-8-273835.html

Category:Active Pharmaceutical Ingredients > Other Active Pharmaceutical Ingredients
Product Name:96%-102% CARMUSTINE 154-93-8
CAS No.:154-93-8
Standard:USP, BP, EP, JP, In-house Standards
Price(USD):Negotiable
Company:Sinoway Industrial Co.Ltd.

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Product Information

Product name	Carmustin
Molecular Formula	C5H9Cl2N3O2
Molecular Weight	214.05
CAS No.	154-93-8
Quality Standard	96.0-101.0% up, medical grade
Appearance	White powder

COA of Carmustin

TEST ITEMS	SPECIFICATIONS	RESULTS
Characteristics	A YELLOWISH CRYSTALS, OR CRYSTALLINE POWDER. ODOURLESS, VERY SLIGHTLY SOLUBLE IN WATER, FREELY SOLUBLE IN ETHANOL.	Conforms
Identification	1.POSITIVE 2.POSITIVE 3, MAXIMUM ABSORPTION AT THE WAVELENGTH OF 230NM	Conforms
MELTING RANGE	30℃-32℃, MELTS WITH DECOMPOSITION	30.7℃-31.7℃, MELTS WITH DECOMPOSITION
LOSS ON DRYING	≤0.5%	0.36%
CLARITY OF SOLUTION	CLEAR	CONROMS 0.1 %
COLOR OF SOLUTION	< YG5	< YG5
RESIDUE SOLVENTS 1, DMF 2,EHTANOL 3,ISOPROPYL ALCOHOL	0.088% MAX 0.5% MAX 0.5% MAX	< 0.088% < 0.5% < 0.5%
RELATED SUBSTANCE	3.0% MAX	0.62%
INDIVIDUAL IMPURITY	1.5% MAX	0.16%
RESIDUE ON IGNITION	0.1% MAX	0.03%
HEAVY METALS	20PPM MAX
Assay(BY UV)	96.0% - 101.0%, CALCULATED BASED ON DRIED SUBSTANCE	99.68%

Usage

Function of Carmustine
Carmustine is a nitrosourea alkylating agent. Although it has a chloroethyl group in its structure, its chemical reaction is different from that of nitrogen mustard. Because it can penetrate the blood-brain barrier, it is often used for brain tumors and intracranial metastases.

It is now believed that this product forms isocyanate and diazonium hydroxide through the action of OH- ions under physiological conditions after entering the body. Isocyanates carbamylate proteins, and diazonium hydroxide generates carbanion ions to alkylate biological macromolecules. Isocyanate can inhibit DNA polymerase, inhibit DNA repair and RNA synthesis. This product is a periodic non-specific drug, and it is not completely cross-resistant with general alkylating agents. The resistance of nitrite drugs has little to do with multi-drug resistance genes. This product has high fat solubility. Permeable to the blood-brain barrier, the concentration in cerebrospinal fluid is 50% to 70% of the plasma concentration. It is mainly metabolized in the liver. The metabolites stay in the plasma for several days and still have anticancer effects. They are slowly released after binding to the protein and have a lasting effect.

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96%-102% CARMUSTINE 154-93-8

Product Information

Product name

Carmustin

Molecular Formula

C5H9Cl2N3O2

Molecular Weight

214.05

CAS No.

154-93-8

Quality Standard

96.0-101.0% up, medical grade

Appearance

White powder

COA of Carmustin

TEST ITEMS

SPECIFICATIONS

RESULTS

Characteristics

A YELLOWISH CRYSTALS, OR CRYSTALLINE POWDER. ODOURLESS, VERY SLIGHTLY SOLUBLE IN WATER, FREELY SOLUBLE IN ETHANOL.

Conforms

Identification

1.POSITIVE

2.POSITIVE

3, MAXIMUM ABSORPTION AT THE WAVELENGTH OF 230NM

Conforms

MELTING RANGE

30℃-32℃, MELTS WITH DECOMPOSITION

30.7℃-31.7℃, MELTS WITH DECOMPOSITION

LOSS ON DRYING

≤0.5%

0.36%

CLARITY OF SOLUTION

CLEAR

CONROMS 0.1 %

COLOR OF SOLUTION

< YG5

< YG5

RESIDUE SOLVENTS

1, DMF

2,EHTANOL

3,ISOPROPYL ALCOHOL

0.088% MAX

0.5% MAX

0.5% MAX

< 0.088%

< 0.5%

< 0.5%

RELATED SUBSTANCE

3.0% MAX

0.62%

INDIVIDUAL IMPURITY

1.5% MAX

0.16%

RESIDUE ON IGNITION

0.1% MAX

0.03%

HEAVY METALS

20PPM MAX

Assay(BY UV)

96.0% - 101.0%, CALCULATED BASED ON DRIED SUBSTANCE

99.68%

Usage

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