8-Hydroxyquinoline 148-24-3

Molecular formula: C9H7NO

Molecular weight: 145.16

8-hydroxyquinoline

8-hydroxyquinoline

CAS no. : 148-24-3

MDL number: MFCD00006807

EINECS no. : 205-711-1

RTECS number: VC4200000

BRN number: 114512

PubChem number: 24855220

Dissolve situation

Soluble in ethanol, acetone, chloroform, benzene and mineral acids, almost insoluble in water.

8-hydroxyquinoline is amphoterous, soluble in strong acids and bases, ionized into negative ions in bases, can bind hydrogen ions in acids, and has the lowest solubility at PH=7.

The main purpose

1, widely used in the determination and separation of metals. A precipitating and extracting agent for the precipitation and separation of metal ions, capable of complexing with the following metal ions: Cu? + 2, Be? + 2, Mg? + 2, Ca? + 2, the Sr? + 2, Ba? + 2, zinc? + 2, Cd? + 2, Al? + 3, Ga? + 3, In? + 3, Tl? + 3, Yt? Plus 3, La plus 3, Pb? + 2, B? + 3, Sb? , Cr + 3? + 3, MoO? + 22, Mn? + 2, Fe? + 3, Co? + 2, Ni? + 2, Pd? + 2, Ce? + 3

1. As a pharmaceutical intermediate, it is the raw material for the synthesis of kexelinine, chloroiodoquinoline and fluoxamine, as well as the intermediate of dyes and pesticides. The product is an intermediate of the halogenated quinoline antiamoeba drugs, including quinoidoform, chloroiodoquinoline, diiodoquinoline, etc. By inhibiting intestinal symbionts, these drugs play an anti-amoeba role and are effective against amoeba dysentery, but have no effect on extralimentary amoeba. It has been reported abroad that this kind of drug can cause subacute spinal cord optic neuropathy, so this drug has been banned in Japan and the United States. 8-hydroxyquinoline is also an intermediate of dyes and pesticides. Its sulfates and copper salts are excellent preservatives, disinfectants and fungicides. It is an indicator of complexometric titration for chemical analysis.

2. As a complexing agent and extraction agent for precipitation and separation of metal ions, it can Be combined with Cu+2, Be+2, Mg+2, Ca+2, Sr+2, Ba+2 and Zn? +2, Cd+2, Al+3, Ga+3, In+3, Tl+3, Yt+3, La +3, Pb+2, B+3, Sb? +3, Cr+3, MoO? Complexation of various metal ions, such as +22, Mn+2, Fe+3, Co+2, Ni+2, Pd+2, Ce+3, etc. Standard for the determination of heterocyclic nitrogen by organic microanalysis, organic synthesis. It is also an intermediate of dyes, pesticides and halogenated quinoline antiamoeba drugs. Its sulfates and copper salts are excellent preservatives.

3. Adding epoxy resin adhesive can improve the bonding strength and heat resistance of metal (especially stainless steel), the dosage is generally 0.5 ~ 3 parts. It is the intermediate of quinoline halide antiamoeba drugs, and also the intermediate of pesticide and dye. It can be used as a stabilizer for fungicides, industrial preservatives, polyester resins, phenolic resins and hydrogen peroxide, and as an indicator for complexation titration in chemical analysis.

4. This product is the intermediate of quinoline halides, as well as the intermediate of dyes and pesticides. Its sulfates and copper salts are excellent preservatives, disinfectants and fungicides. The maximum allowable content (quality score) of cosmetics is 0.3%. Sunscreen products and products for children under 3 years old (such as talc) should be banned, and "children under 3 years old should not be allowed" should be marked on the product label. The mass fraction of 8-hydroxyquinoline in the emulsion was 0.001% ~ 0.02% in the treatment of bacterial skin and bacterial eczema. It is also used as a disinfectant, antiseptic and fungicide, and has a strong antifungal effect. The content (mass fraction) of 8- hydroxyquinoline sulfate in skin care creams and lotions was 0.05% ~ 0.5%.