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Email :PharmaSources@imsinoexpo.com
Whatsapp :+86-13621645194
Main Sales Markets: North America,Central/South America,Western Europe,Eastern Europe,Australasia,Asia,Middle East
Monthly Production Capacity: 1000kg
Packaging Information: 25kg/drum 1kg/bottle
Delivery Lead Time: 7 days after payment
Sample Provided: yes
Payment Terms: L/L
Product Information
Product name
Polymyxin B Sulphate
CAS No.
1405-20-5
Molecular Formula
C56H100N16O17S
Molecular Weight
1301.56
Quality Standard
6500IU/MG up /Medicine Grade
Appearance
White powder
COA of Polymyxin B Sulphate
ITEMS
SPECIFICATION
RESULTS
DESCRIPTION
WHITE TO ALMOST WHITE POWDER, HYGROSCOPIC.
CONFORMS
SOLUBILITY
FREELY SOLUBLE IN WATER; SLIGHTLY SOLUBLE IN ALCOHOL.
CONFORMS
IDENTIFICATION
A. LIQUID CHROMATOGRAPHIC IDENTIFICATION TEST
B. A REDDISH VIOLET COLOR IS PRODUCED
C. TEST FOR SULFATE
CONFORMS
PH(2%)
5.0~7.0
5.7
PH(0.5%)
5.0~7.5
5.5
SPECIFIC ROTATION
-78°- -90°
-80.0°
LOSS ON DRYING
NOT MORE THAN 7.0%
4.7%
PHENYLALANINE
9.0%~12.0%
10.31%
SULPHATED ASH
NOT MORE THAN 0.75%
0.31%
SULPHATE
15.5%~17.5%
16.53%
HEAVY METALS
NOT MORE THAN 20PPM
<20PPM
ASSAY(MICROBIAL)
(ON DRIED BASIS)
NOT LESS THAN 6500IU/MG
8220 IU/MG
PARTICLE SIZE
99.0%:NOT MORE THAN 30UM BY VOL.
90.0%:NOT MORE THAN 25UM BY VOL.
75.0%:NOT MORE THAN 20UM BY VOL.
MEAN DIAMETER:NOT MORE THAN 8.0UM
CONFORMS
CONCLUSION:THE RESULTS CONFORM TO THE STANDARD OF USP34
Usage
Function of Polymyxin B Sulphate
Polymyxin B sulphate is similar to polymyxin E. It can inhibit gram-negative bacilli such as Escherichia coli, Pseudomonas aeruginosa, Para Escherichia coli, Klebsiella pneumoniae, Acidophilus, Pertussis and Shigella, etc. Or bactericidal effect. It is mainly used for Pseudomonas aeruginosa and other Pseudomonas to cause the wounds, urinary tract, eyes, ears, trachea and other parts of the Chemicalbook infection. It can also be used for sepsis and peritonitis. And resistant to aminoglycosides, resistant to third-generation cephalosporin bacteria and Pseudomonas aeruginosa or other sensitive bacteria caused by serious infections, such as bacteremia, endocarditis, pneumonia, post-burn infections, etc.
Polymyxin B is a peptide antibiotic against gram-negative bacilli, which can change the membrane structure to leak small molecules and inhibit the growth of gram-negative bacteria. Has a bactericidal effect on E. coli Chemicalbook. Binds to the lipid A portion of bacterial lipopolysaccharides. Inducing small holes in the outer cell membrane. Mode of action: Combine and interfere with the permeability of the cell plasma membrane. Antibacterial spectrum: Gram-negative bacteria.