6500IU/MG up, USP Polymyxin B Sulphate 1405-20-5

Category:Active Pharmaceutical Ingredients > Other Active Pharmaceutical Ingredients
Product Name:6500IU/MG up, USP Polymyxin B Sulphate 1405-20-5
CAS No.:1405-20-5
Standard:USP, BP, EP, JP, In-house Standards
Price(USD):Negotiable
Company:Sinoway Industrial Co.Ltd.

Basic Info
  • Grade: Pharmaceutical Grade

    Factory Location: Xiamen, Fujian

    Main Sales Markets: North America,Central/South America,Western Europe,Eastern Europe,Australasia,Asia,Middle East

  • Monthly Production Capacity: 1000kg

    Packaging Information: 25kg/drum 1kg/bottle

  • Delivery Lead Time: 7 days after payment

    Sample Provided: yes

    Payment Terms: L/L

     

    Product Information

     

    Product name

    Polymyxin B Sulphate

    CAS No.

    1405-20-5

    Molecular Formula

    C56H100N16O17S

    Molecular Weight

    1301.56

    Quality Standard

    6500IU/MG up /Medicine Grade

    Appearance

    White powder

     

    COA of Polymyxin B Sulphate

     

    ITEMS

    SPECIFICATION

    RESULTS

    DESCRIPTION

    WHITE TO ALMOST WHITE POWDER, HYGROSCOPIC.

    CONFORMS

    SOLUBILITY

    FREELY SOLUBLE IN WATER; SLIGHTLY SOLUBLE IN ALCOHOL.

    CONFORMS

    IDENTIFICATION

    A. LIQUID CHROMATOGRAPHIC IDENTIFICATION TEST

    B. A REDDISH VIOLET COLOR IS PRODUCED

    C. TEST FOR SULFATE

    CONFORMS

    PH(2%)

    5.0~7.0

    5.7

    PH(0.5%)

    5.0~7.5

    5.5

    SPECIFIC ROTATION

    -78°-   -90°

    -80.0°

    LOSS ON DRYING

    NOT MORE THAN 7.0%

    4.7%

    PHENYLALANINE

    9.0%~12.0%

    10.31%

    SULPHATED ASH

    NOT MORE THAN 0.75%

    0.31%

    SULPHATE

    15.5%~17.5%

    16.53%

    HEAVY METALS

    NOT MORE THAN 20PPM

    <20PPM

    ASSAY(MICROBIAL)

    (ON DRIED BASIS)

    NOT LESS THAN 6500IU/MG

    8220 IU/MG

    PARTICLE SIZE

    99.0%:NOT MORE THAN 30UM BY VOL.

    90.0%:NOT MORE THAN 25UM BY VOL.

    75.0%:NOT MORE THAN 20UM BY VOL.

    MEAN DIAMETER:NOT MORE THAN 8.0UM

     

     

    CONFORMS

    CONCLUSION:THE RESULTS CONFORM TO THE STANDARD OF USP34

     

    Usage

     

    Function of Polymyxin B Sulphate

    Polymyxin B sulphate is similar to polymyxin E. It can inhibit gram-negative bacilli such as Escherichia coli, Pseudomonas aeruginosa, Para Escherichia coli, Klebsiella pneumoniae, Acidophilus, Pertussis and Shigella, etc. Or bactericidal effect. It is mainly used for Pseudomonas aeruginosa and other Pseudomonas to cause the wounds, urinary tract, eyes, ears, trachea and other parts of the Chemicalbook infection. It can also be used for sepsis and peritonitis. And resistant to aminoglycosides, resistant to third-generation cephalosporin bacteria and Pseudomonas aeruginosa or other sensitive bacteria caused by serious infections, such as bacteremia, endocarditis, pneumonia, post-burn infections, etc.

     

    Polymyxin B is a peptide antibiotic against gram-negative bacilli, which can change the membrane structure to leak small molecules and inhibit the growth of gram-negative bacteria. Has a bactericidal effect on E. coli Chemicalbook. Binds to the lipid A portion of bacterial lipopolysaccharides. Inducing small holes in the outer cell membrane. Mode of action: Combine and interfere with the permeability of the cell plasma membrane. Antibacterial spectrum: Gram-negative bacteria.

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