5-Aminolevulinic Acid HCl (5-ALA) for PDT 5451-09-2

Basic Information

Product Name 

5-Aminolevulinic acid hydrochloride (5-ALA HCL)

Other  Name 

5-Amino-4-oxopentanoic acid;5-Amino-4-oxovaleric acid

Specification

 99%.0 by HPLC

Cas No.

 5451-09-2

Molecular Formula

C5H9NO3HCl

 Molecular Weight

167.591 

 Melting point

145°C-148°C

Chemical Structure

Appearance

White Fine Powder

Odor& Taste

Characteristic

Product

TEST ITEM

SPECIFICATION

RESULTS

Appearance 

   Almost white powder

Almost white powder

Identification 

FT-IR,HPLC,NMR,Mass

Confirm

Loss on drying

NMT T1.0%

0.40%

Melting point

135°C

145.5°C

Residue on ignition

0.5%

0.11%

Heavy metals

NMT 20ppm

Confirm

Iron

NMT20ppm

Confirm

Bacteria endotoxins

NMT0.4 USP EU/mg

0.2 EU/mg

Microbial  Limits

Total aerobic microbial count

NMT100 cfu/g

Confirm

Staphylococcus aureus

Absence

Absence

Pseudomonas aeruginosa

Absence

Absence

Salmonella species

Absence

Absence

Escherichia Coli

Absence

Absence

Impurities

Any other single impurity

NMT0.3%

Confirm

Total impurities

NMT1.0%

0.48%

Assay

98.0%-102.0%

99.79%

Conclusion

The lot meets the specifications

 Function 

  5-ALA is applied in variety of scientific fields with wide range. Examples of applications are shown below. Improvement of harvest yield or increase of plant greenness Supplement for culture of microorganism or cells from animals Research relating production of active oxygen derived from accumulation of excess amount of porphirins Photodynamic diagnosis for cancer research.

1. 5-ALA is used in variety ways to treat skin problems and also in cosmetics. It works extremely well on the skin cancer patient and acne problems. It is also used in photo dynamic therapy and has trichosis effects.
2. 5-ALA is usesd in area of  Photodynamic therapy (photodynamic therapy, PDT).
3. 5-ALA can also be used in fertilizer and bio-degradable herbicide. The functional fertilizer that activates the photosynthesis when it is applied to leaves
   • Biodegradable photodynamic substance
   • Increase chlorophyll biosynthesis (ALA -> tetrapyrrote -> Chlorophyll)
   • Increases tolerance to environmental shock stress (Low temperature, salt accumulation, lack of sunlight)
   • Speed up photosynthesis (Increase yield of the crops and sugar content)
4. Replace the use of antibiotics.
   • It is a known fact that 5-ALA is used to produce high quality meat because it has no anti-resistant bacteria and promote growth.    However due to high cost of 5-ALA, not everyone can afford to use 5-ALA. 
   • Effective immunoadjuvant.

Storage

Storage: Store in cool & dry place, Keep away from strong light and heat. 
Shelf life: 24 Months when properly stored. 

Packing 

N.W.: 25 kgs   

G.W.:28 kgs

Paper-drums for outer and two plastic-bags inside