4-Dimethylaminopyridine 1122-58-3

Melting point 113~114℃ boiling point 211℃ water-soluble 76 g/L (25℃) density 0.906 g/cm3 at 25℃ exterior white crystal powder should be described with a new high-efficiency catalyst for chemical synthesis 36/37/39-45-28a-26-28-36/37-53-27-22-16 dangerous symbol Dangerous goods transport no. UN 2811 6.1/PG 2

4 - dimethyl aminopyridine is widely used in chemical synthesis in recent years a new type of high efficient catalyst, dimethyl amine and its structure for electronic mother ring resonance (pyridine ring), can strongly activated nucleophilic ring of nitrogen atoms to replace, significantly high resistance, low reactivity of alcohol and amine acylation (phosphorus acylation, sulfonyl, carbonyl) reaction, the activity is about 104-6 times of pyridine. In organic synthesis, drug synthesis, pesticide, medicine, dyes, spices, polymer chemistry, analytical chemistry in the acylation and alkylation, etherification, esterification and transesterification and various types of reactions, have higher catalytic ability, has the extremely obvious effect to improve the yield, moreover can also be used as a phase transfer catalyst used in the interface reaction. Its advantages are as follows: the amount of catalyst is small, usually only 0.01~5% of the mole number of reaction substrate can be used, and the acid produced by the reaction can be neutralized by organic or inorganic alkali. The reaction conditions are mild and can be carried out at room temperature to save energy. Wide range of solvent selection, in polar and non-polar organic solvents can be carried out; The reaction time is short, with pyridine reaction for a long time, and DMAP reaction is completed in a few minutes, thus greatly improving labor productivity. High yield, such as the use of pyridine almost no reaction of the steric resistance of hydroxyl compounds, the use of DMAP yield can be up to 80~90%, which can improve the yield and product quality and simplify the process. Less side effects, less odor, less waste; Because of its excellent catalytic performance, DMAP is called "super catalyst", and it has become one of the most commonly used catalysts for organic synthesis