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Category:Active Pharmaceutical Ingredients
Product Name:4-AMINO BENZOIC ACID 150-13-0
CAS No.:150-13-0
Standard:In-house Standards
Price(USD):1.00
Company:Hangzhou Dingyan Chem Co., Ltd
Grade: Pharmaceutical Grade
Factory Location: hangzhou
Main Sales Markets: North America,Central/South America,Western Europe,Eastern Europe,Australasia,Asia,Middle East,Africa
Sample Provided: no
Properties: colorless needle crystal. Light yellow in air or light. It is moderately toxic. Irritation of skin and mucous membranes. Rinse with water immediately after contact with skin.
Structural formula for p-aminobenzoic acid
Structural formula for p-aminobenzoic acid
Melting point: 187 ~ 187.5 ℃
Density: 1.374 g/mL at 25 ° C
Solubility: soluble in hot water, ethyl ether, ethyl acetate, ethanol and glacial acetic acid, insoluble in water, benzene, insoluble in petroleum ether.
use
Used in dyes and pharmaceutical intermediates. Used for the production of reactive red m-80, m-10b, reactive red purple x-2r and other dyes, as well as the production of cyanobenzoic acid to produce drug p-carboxybenzylamine. Para aminobenzoic acid can be used as sunscreen. Its derivative, octyl para dicarbamate, is an excellent sunscreen
(1) obtained from reduction of p-nitrobenzoic acid.
(2) it is prepared from p-nitrotoluene by REDOX.
(3) using p-methylaniline as raw material, it was prepared by acetylation, oxidation and reduction.
The p-aminobenzoic acid is catalyzed by dihydrofolate synthase to synthesize dihydrofolate with dihydropteridine pyrophosphate and glutamate or dihydropteridine pyrophosphate and p-aminobenzoyl glutamate. Dihydrofolate is then reduced to tetrahydrofolate under the catalysis of dihydrofolate reductase, which is further synthesized to obtain coenzyme F, providing a carbon unit for bacteria to synthesize DNA bases. As derivatives of p-aminobenzene sulfonamide, sulfonamides are similar to substrate p-aminobenzoic acid in structure, molecular size and charge distribution, so they can replace p-aminobenzoic acid in the synthesis of dihydrofolate and block the synthesis of dihydrofolate. This leads to microbial folate synthesis being blocked and life not prolonged.
The reversible conversion of p-aminobenzoic acid to gluronic acid esters in the cytoplasm under the catalysis of gluronyl transferases results in the esterification of all or most of the p-aminobenzoic acid in plants, which may be a storage and transport form of p-aminobenzoic acid in plants.
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