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Secondary alcohol is an important class of compounds, not only important organic intermediates, but also widely used in fine chemicals such as drugs, pesticides and fragrances. In the traditional method, high temperature and high pressure hydrogenation can be used, inorganic reducing agents such as sodium borohydride can be added, or formic acid and sodium formate can be used to prepare secondary alcohols, which have safety risks in the reaction process and produce a large amount of waste, causing certain pollution to the environment. In recent years, the use of isopropanol Chemicalbook, a cheap, safe and non-toxic hydrogen donor, has received widespread attention. However, strong or weak bases need to be added during the reaction. Therefore, from the perspective of organic synthesis, the development of a new class of organometallic catalysts, through the use of cheap, safe and non-toxic isopropanol as a hydrogen source and solvent, does not need to add alkali to the reaction, can catalyze such reactions in an environmentally friendly and mild state is of great significance.
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Pharma Sources Insight June 2024: Globalization on the Go
