1,7-Heptanediol 629-30-1

Physical and chemical properties

Appearance and properties: transparent colorless liquid above room temperature after melting point

Density: 0.951 g/mL at 25 ° C (lit.)

Melting point: 17-19 ° C (lit.)

Boiling point: 259 ° C (lit.)

Flash: > 230 ° F

Index of refraction: n20/D 1.455(lit.)

Production methods

It was obtained from heptanolactam ([673-66-5]) through thiosubstitution and reduction.

1. Glucosinolates will heptyl lactam add water, heating to begin phosphorus pentasulfide and 60 ℃, the temperature control in 85-95 ℃, about 1.5 h adds. Up to 115-118 ℃, mixing reaction 0.5 h. Temperature of 105 ℃, drops of water, the decomposition of 1 h. Cool to 30 ℃, filtering. After the filtrate was cooled and crystallized, the crude product of thioheptanolamide was prepared. The refined thioheptanolactam was obtained by combining crude substance dissolved in alcohol, decolorization, filtration and crystallization with activated carbon.

2. Reduction to ethanol, refined glucosinolates heptyl lactam boron and potassium hydrogen mixed with reaction pot, heated to 74 ℃, under reflux drops of water, about 3 h adds, continue to return 1 h. Cooling below 30 ℃, and hydrochloric acid to pH value is 1. Heat it up to a boil and remove the hydrogen sulfide. Distillation recycling ethanol and then cooled to below 20 ℃, liquid alkali to pH for 14. Steam distillation is then carried out. The distillate was extracted with xylene, dried and filtered with anhydrous sodium carbonate, and the solution of cycloheptathimide xylene was obtained. The dissolved product is obtained.