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Amyloid beta from natural state to oligomers, and fiber will induce a series of neurodegenerative diseases.
Amyloid beta is prone to fold, and the shorter sequence is not likely to happen space fold, Amyloid beta Protein (1-28) selection of Amyloid beta 28 amino acid as the research object, in general, the stability of the short peptide is slightly better than long peptide.
But in the Amyloid beta Protein (1-28), prone to the Asn, ihs amino acid hydrolysis is more, so the Amyloid beta Protein (1-28) stability is not good.
Usually the Amyloid beta Protein (1-28) products to make Tfa salt form.
In mass production, Fmoc - Phe - Phe - OH can be used as raw material, the advantage is to improve the production efficiency, can produce a purity higher crude products at the same time.
In the second half of the sequence, His number is more, it is recommended to use HOBT/DIC as a condensation agent.
Storage: - 20 ℃ under freeze dry, avoid light preservation remark: used only for research, not for human body