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Patient death following CAR-T therapy highlights serious manufacturing issues pharmaceutical-technology
October 08, 2018
It is reported that the accidental genetic engineering of a single leukemic cell during the early manufacturing of CAR-T therapy tisagenlecleucel for a phase I study caused the relapse and eventual death of one patient participating in the clinical trial.
Sophiris Bio Releases Report on Patient Death americanpharmaceuticalreview
August 31, 2018
Sophiris Bio announced the conclusion of the ongoing investigation into the previously reported death of a patient in the company's Phase 2b trial for the treatment of localized prostate cancer is unlikely to be related to either topsalysin or the procedu
Patient death sparks safety worries in Ionis trial pharmafile
May 17, 2017
Ionis Pharmaceuticals announced the results from a Phase 3 trial of its drug to treat patients with familial amyloid polyneuropathy and the results were extremely positive, except for the side-effects.