This article explores antisense oligonucleotides (ASOs) in gene silencing, covering their mechanism, development, applications, pros and cons, and future delivery challenges.
GlaxoSmithKline has jilted Ionis Pharmaceuticals just before the pair was due to file for approval of inotersen. The action furthers recently installed GSK CEO Emma Walmsley’s plan to purge the Big Pharma of its rare disease programs.