ProBioGen and DIOSynVax Partner to Manufacture Groundbreaking Multivalent Vaccine for Hemorrhagic Fever

ProBioGen, a globally recognized and experienced Contract Development & Manufacturing Organization (CDMO), proudly announces a partnership with DIOSynVax Ltd to manufacture DIOS-HFVac3, a trivalent hemorrhagic fever (HF) vaccine that was developed in collaboration with Prof. Wagners team (Molecular Virology, Institute of Medical Microbiology and Hygiene, University of Regensburg). The novel vaccinetargets HF diseases caused by Ebola, Marburg, and Lassa viruses. Epidemics of viral hemorrhagic fevers are a major public health concern and a major economic burden. Especially the increase of simultaneous epidemics in low and middle-income African regionsstresses the urgency of a multivalent vaccine produced on a production platform resilient against supply limitations. The pre-clinical efficacy of the novel trivalent vaccine has been demonstrated in challenge studies in animal models. ProBioGen’s MVA CR19vector will be used to deliver the three HF vaccine antigens.

DIOS-HFVac3 will be manufactured on ProBioGen's cutting-edge industrial platform, which was developed for the production of a broad range of viral vaccines. The platform consists of the company’s proprietary AGE1.CR.pIX suspension cellline, proprietary chemically defined media and advanced scalable production and purification process. Under the terms of the agreement, ProBioGen will conduct process and analytical development followed by manufacturing of DIOS-HFVac3 for clinical trials andsubsequent regulatory approval.

"Our collaboration with DIOSynVax represents a significant milestone in ProBioGen's journey," said Dr. Volker Sandig, Chief Scientific Officer at ProBioGen. "Our innovative platform for the manufacturing of DIOS-HFVac3 underscores our commitment to advancing robust and resilient biopharmaceuticalsolutions for global health challenges, independent of the geographic region where these challenges may occur."

"This project marks the company's dedication to pioneering technologies and expanding its service value chain. "We are thrilled to embark on this transformative journey with DIOSynVax," stated Dr. Lutz Hilbrich, CEO of ProBioGen. "This partnership exemplifies our unwavering commitment to driving advancements in biopharmaceutical manufacturing and delivering life-saving therapiesto those in need."

DIOSynVax's CEO Prof. Jonathan Heeney expressed confidence in the collaboration, emphasizing ProBioGen's role as a trusted partner. "We are delighted tocontinue our fruitful partnership with ProBioGen," stated DIOSynVax's CEO. "Their expertise, dedication, and collaborative spirit have been instrumental in our joint efforts. Together, we are poised to make a significant impact by bringing this vital vaccineto developing countries, mainly in Africa."

This research is funded by the Department of Health and Social Care as part of the UK Vaccine Network (UKVN), a UK Aid program to develop vaccines for diseases with epidemic potential in low and middle-income countries (LMICs).