Three Elements of Rational Use of Antibiotics

The clinical pharmacological concept of rational use of antibiotics is the safe and effective use of antibiotics, that is, ensuring effectiveness under the premise of safety, which is the basic principle of rational use of antibiotics. Clinicians should have a basic understanding of the possible adverse reactions during the application of antibiotics. Antibiotics are used in a large amount, a wide range, a variety of varieties, and a rapid update, and the interaction between various drugs is complex.

1. Selection of antibiotics

The basic principle of antibiotic treatment is to be targeted. First of all, it is necessary to master the antibacterial spectrum of different antibiotics. Each antibiotic has different action characteristics, so the antibacterial spectrum of the selected drug must be suitable for the microorganisms infected.

Antibiotic pathogens are selected according to the sensitivity of pathogenic bacteria, and the sensitivity to antibiotics is not fixed. Some bacteria that are prone to drug resistance, such as Vitis vinifera, Pseudomonas aeruginosa, Enterobacter, etc., have increased resistance to many commonly used antibiotics in recent years. Therefore, with the help of correct drug susceptibility results, it can help clinicians choose antibiotics correctly and increase the success rate of clinical infection treatment. Antibiotics with strong effects and high blood and tissue concentrations are selected according to the law and severity of infectious diseases.

2. Dosage of antibiotics

The therapeutic effects of different doses of antibiotics are quite different. In general, the larger the dose within a certain range, the higher the concentration of the drug in the body, and the more significant the curative effect. You could buy antibiotics on Pharmasources. A common mistake people make about dosing antibiotics is underdosing each time for more serious infections. Or the interval between each medication is too long, or the medication is effective and the use is reduced or discontinued, which makes the bacteria in the body re-emerge, so it is difficult to obtain the best effect. Therefore, the use of antibiotics should pay attention to be sufficient and on time. That is, 4 times a day should be administered every 6 hours, and 3 times a day should be administered every 8 hours (rather than after each meal). Even if the curative effect is obtained, it should be administered in sufficient doses, generally 5 to 7 days as a course of treatment.

3. Use of antibiotics

Whether antibiotics are used correctly or not directly affects the efficacy. The absorption degree and rate of different antibiotics are also different, generally 1 to 2 hours after oral administration, 0.5 to 1 hour after intramuscular injection, the drug is absorbed into the blood, and the blood concentration reaches a peak. The most common way people use antibiotics is the wrong route of administration. When people self-administer antibiotics, most of them are inconvenient to take oral administration. This is less effective for certain site-specific and more severe infections. Therefore, for common diseases such as infectious high fever, tonsillar purulent infection, severe bronchitis, severe acute gastroenteritis, and specific site infections such as otitis media, adnexitis, cholecystitis, etc., it is best to use intramuscular injection or intravenous infusion of antibiotics to quickly control the infection and avoid delaying the disease.