Mechanisms of Antibiotic Therapeutic Action

Ⅰ. The concept of rational use of antibiotics

The clinical pharmacological concept of rational use of antibiotics is the safe and effective use of antibiotics, that is, ensuring effectiveness under the premise of safety, which is the basic principle of rational use of antibiotics. Under normal circumstances, most of the new antibiotics will lose their original effectiveness due to the resistance of bacteria within a few years. However, incorrect use has exacerbated the rapid growth of drug-resistant bacteria.

Due to the large amount of clinical application of antibiotics, the variety of antibiotics, the rapid update, and the complex relationship between various drugs, the combination of drugs is increasing day by day, and the preventive drugs are becoming more and more extensive. Therefore, the incidence of adverse reactions and drug resistance of clinical antibiotics is still increasing year by year. Rational use of antibiotics requires specific patient-specific analysis and individualized treatment plans. There is no one fixed scheme that can be used in different situations. If you are looking for different types of antibiotics drugs, Pharmasources would be a great platform for you.

Ⅱ. How do antibiotics work?

There are many types of antibiotics, and there are no less than dozens of antibiotics in daily use in medicine and veterinary medicine. Different antibiotics work differently on germs:

1. Some antibiotics interfere with the synthesis of bacterial cell walls, causing bacteria to swell, rupture and die due to lack of complete cell walls, which cannot resist the invasion of water;

2. Some antibiotics damage the cell membrane of bacteria, and the bacteria die due to the loss of internal substances.

3. Some antibiotics can hinder the protein synthesis of bacteria and stop the reproduction of bacteria.

4. Some antibiotics change the internal metabolism of bacteria and affect the synthesis of its DNA, so that bacteria (and tumor cells) cannot reproduce new cellular substances and die. There are many types of antibiotics, which can be classified according to their chemical properties. It can also be classified according to the scope of antibacterial (antibacterial spectrum).

In addition, they can also be divided into reproductive period bactericidal antibiotics, stationary phase bactericidal antibiotics, rapid bacteriostatic antibiotics and slow-acting bactericidal antibiotics. In the current treatment practice, antibiotics are usually classified according to the scope of antibacterial, that is, antibiotics are divided into anti-Gram-positive bacteria antibiotics, anti-Gram-negative bacteria antibiotics and broad-spectrum antibiotics. Negative bacteria have antibacterial effect. In addition, some antibiotics that specifically inhibit or kill mold are listed as antifungal antibiotics.