Vitamin B1 API Manufacturers in China

1.What is Vitamin B1?

Definition:

Vitamin B1, also known as thiamine or thiamin,  is a water-soluble vitamin that belongs to the vitamin B family and was the first one discovered by scientists. 

It was discovered by Umetaro Suzuki in Japan while researching how rice bran could help patients with Beriberi.

Thiamine is essential for glucose metabolism because it converts carbohydrates and fat into energy and the normal growth and function of various cells in the heart, nervous system, muscles, and digestive system.

Thiamine is used to treat conditions related to low levels of thiamine (vitamin B1) and niacin (vitamin B3), as well as Korsakov's alcoholic psychosis, Wernicke-Korsakov syndrome (WKS), delirium, beriberi, and peripheral nerves inflammation (neuritis).

Vitamin B1 (thiamine) is a nutrient that can be found in nature in various food sources, including yeast, meat, fish, legumes, whole grains, and nuts, as well as added to food or purchased as a supplement. 

Thiamine is a heat-labile vitamin that can be destroyed by high-heat cooking or long cooking times and being removed during food processing.

Because the body stores only a small amount of vitamin B1, daily use of thiamine-rich food must be included in the diet.

Amazon.com: Nutricost Vitamin B1 (Thiamine) 500mg, 120 Capsules: Health &  Personal Care

YAMAMOTO RESEARCH Vitamina B1

• Chemical & Physical properties:

• Chemical structure:

• Synonyms: Thiamine hydrochloride

• Molecular formula: C12H17ClN4OS

• Molecular weight: 300.81

• Melting point: 164 °C

• CAS number: 59-43-8
  

• DrugBank accession number: DB00152

• IUPAC name: 2-[3-[(4-amino-2-methylpyrimidin-5-yl)methyl]-4-methyl-1,3-thiazol-3-ium-5-yl]ethanol;chloride

• Color/Form: Crystals from water

• Water solubility: Soluble in water and insoluble in alcohol

• Stability/Shelf Life: Under normal storage conditions, it is stable; however, it degrades in neutral and alkaline solutions.

• Brand names:

• Alertonic®, Concept Ob®, Fortaplex®, Infuvite®

2.Mechanism of action of Vitamin B1

Thiamine forms thiamine pyrophosphate (TPP) when it reacts with adenosine triphosphate (ATP) in the liver, kidneys, and leukocytes. TPP is an essential coenzyme for carbohydrate metabolism, energy production, cell viability, and proper neuronal function.

3.Forms and specifications of Vitamin B1

• Vitamin B1 API powder 99%

Anhui Sinotech Industrial Co.,Ltd - The company is engaged in international marketing of top-quality products, including Active Pharmaceutical Ingredients (API), food-feed additives, pesticides, and chemicals. 

Company Name: Anhui Sinotech Industrial Company Limited.

Business Type: Suppliers

Factory Location: Ganquan Road, Tuoji CBC 2305, Anhui, China

Product Name: Thiamine (Vitamin B1) API 

• Vitamin B1 Nitrate (Vitamin B1 Mononitrate) powder 
  

Thiamine mononitrate is a vitamin B1 nitrate salt that has been used to fortify foods and make a variety of multivitamin products.

Thiamine mononitrate API, Raw material powder found in many food and plant, including whole grains, meat, nuts, beans, and pea.

Thiamine mononitrate is preferred over thiamine hydrochloride (HCL) because it is more stable and does not absorb water from ambient humidity (non-hygroscopic), whereas thiamine hydrochloride (HCL) does.

Vitamin B1 Powder ( Thiamine Hydrochloride or Hcl, Thiamine Mononitrate)

Jiangsu Fengshan Group Co., Ltd  .|Trifluralin|Quizalofop-p-ethyl|Glyphosate|Nicosulfuron|Acetamiprid|Imidacloprid|Pesticide  technical and formulations

Vitamin B1 Powder ( Thiamine Hydrochloride Or Hcl, Thiamine Mononitrate, Thiamine Nitrate )

Company Name: FENGCHEN GROUP  COMPANY LIMITED.

Business Type: Suppliers

Factory Location: No.98 Jingson 6th Road, Laoshan District, Qingdao, China

Products: Thiamine hydrochloride (HCL) / Thiamine mononitrate powder raw material, API

• Vitamin B1 Tablets
  

Vitamin B1 (Thiamin) 500 mg Tablets - Solgar

Thiamine (vitamin B1) is used to treat vitamin B1 deficiency in people who do not get enough of it from their food.

Vitamin B1 tablets can be taken orally, with or without food, 1 to 3 times per day.

• Vitamin B1 Injection

Vitamin B1 Injection, 50ml, Rs 100 /pack Sarvasya Trading (India) Private  Limited | ID: 22576797091

Thiamine Hydrochloride 200 mg/2 mL Multi-Dose Vial Pack of 25 USP Injection

Thiamine hydrochloride (HCl) injection is used to treat thiamine deficiency when the oral form is ineffective.

Thiamine hydrochloride (HCl) vials are administered via injection into a muscle or vein as directed by your doctor.

4.Uses of Vitamin B1

• Vitamin B1 for Energy & Metabolism

Amazon.com: BulkSupplements.com Thiamine HCl (Vitamin B1) Powder - Thiamine  100mg - Energy Vitamins for Women (250 Grams): Health & Personal Care

Thiamine (vitamin B1) aids in the breakdown and release of energy from food by converting carbohydrates, lipids, and proteins into energy needed by the body, particularly the brain and nervous system. It is also required for glucose metabolism and aids in muscle contraction.

• Vitamin B1 for Healthy nerve tissue

Thiamine is required for energy and glucose metabolism, which is involved in the maintenance of nerve membrane function and supply of energy to nerve cells.

Thiamine is also involved in synthesizing myelin and many types of neurotransmitters (e.g., acetylcholine, serotonin, and amino acids).

• Vitamin B1 for mosquito bites

Although studies have not proven the use of thiamine pills for mosquito bites, new research suggests that topical thiamine hydrochloride may be effective as a mosquito repellent.

5.Dosage of Vitamin B1

Tablets

• 50mg

• 100mg

• 250mg

Capsules

• 50mg
  

Injectable solution

• 100mg/mL
  

Dosage Considerations and the Recommended Dietary Allowance (RDA).

Adults

• Males: 1.2 mg/day
  

• Females: 1.1 mg/day

• Pregnancy/Lactation: 1.4 mg/day

Pediatric•

• 0-6 months: 0.2 mg/day

• 6-12 months: 0.3 mg/day

• 1-3 years old: 0.5 mg/day

• 3-8 years old: 0.6 mg/day

• 8-13 years old: 0.9 mg/day

• 13-18 years old: 1.2 mg/day (male), 1 mg/day (female)

6.Side effects of Vitamin B1

The most common side-effects related to the use of thiamine are warmth, urticaria, edema, pruritus, nausea, weakness, and tightness of the throat.

7.Vitamin B1 Active Pharmaceutical Ingredients (API) price

The average price of thiamine Active Pharmaceutical Ingredient (API)  is 55.9 (USD/KGS).

8.Vitamin B1 Manufacturing process

The chemical synthesis of thiamine includes the reaction of 5-(beta-hydroxyethyl)-4-methylthiazole with 2-methyl-4-amino-5-bromomethylpyrimidine, hydrogen bromide salt, followed by neutralization and reaction with hydrochloric acid.

9.Vitamin B1 Active Pharmaceutical Ingredients (API) Manufacturers in China

• Zhejiang Medicines & Health Products Imp. & Exp. Co., Ltd.

Exhibitor Detail

The company has been listed in the Catalogue of Top 500 Import & Export Companies in China.

Business Type: Trading Company, Supplier 

Category: Active Pharmaceutical Ingredients 

Factory Location: Hangzhou Zhejiang, China

Product: Thiamine 

Grade: Pharmaceutical grade

• Jiangxi Tianxin Pharmaceutical Co., Ltd.
  

Pyridoxine Hydrochloride API Manufacturers | Suppliers | Drug Master Files  (DMF) | CEP | Pharmacompass.comThe company is one of the top manufacturers and suppliers of vitamins in China, focusing on the production of API, food, and feed additives.

The company's top products include thiamine nitrate and thiamine hydrochloride, besides pharmaceutical equipment, advanced production technology, and production workshops built in accordance with GMP high standards.

The company has a long-term corporation with top domestic universities and scientific research institutions.

Business Type: Trading Company, Supplier 

Category: Active Pharmaceutical Ingredients, API Equipment

Factory Location: China

Product: Thiamine 

Grade: Pharmaceutical grade

• Xinfa Pharmaceutical Co., Ltd.
  

Business Type: Supplier 

Category: Active Pharmaceutical Ingredients

Factory Location: Dongying, Shandong, China

Products: Thiamine Nitrate(salt), Thiamine hydrochloride (HCl)

References:

• https://pubchem.ncbi.nlm.nih.gov/compound/Vitamin-B1#section=Spectral-Information

• https://go.drugbank.com/drugs/DB00152

• https://www.ncbi.nlm.nih.gov/books/NBK482360/

• https://www.hsph.harvard.edu/nutritionsource/vitamin-b1/

• https://reference.medscape.com/drug/vitamin-b1-thiamine-344428

• https://www.rxlist.com/consumer_thiamine_vitamin_b1/drugs-condition.htm

• https://www.medicalnewstoday.com/articles/219545#foods

• https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6930825/

• https://www.jstage.jst.go.jp/article/bpb/43/2/43_b19-00538/_article

• https://www.pharmacompass.com/price/vitamin-b1

• https://www.pharmacompass.com/pharma-services/api-manufacturing-services/anhui-sinotech-industrial

• https://www.webmd.com/drugs/2/drug-14030/thiamine-hcl-vitamin-b1-injection/details