Cefdinir API Market Size & Trends

What is Cefdinir?

Cefdinir is a 3rd generation cephalosporin (antibiotic). It is used to treat gram-negative and gram-positive infections of the sinus, throat, lungs, skin, and ear. 

Cefdinir was patented for use in 1979 and became widely available in the market by 1991. The drug was first approved by the US FDA in 1997 and was marketed by Abbvie. It is a semi-synthetic antibiotic that is typically used against infections that are resistant to the first lie cephalosporin antibiotics. 

Data shows that this drug was the 146th most prescribed drug in 2018 in the US. It was prescribed more than 4 million times to treat different infections. 

• Definition

The drug is a cephalosporin compound that has a 7beta-2-(2-amino-thiazol-4-yl)-2-[(Z)-hydroxyimino]-acetylamino- and 3-vinyl side groups. The drug is both a cephalosporin and a ketoxime in nature. 

• Chemical & Physical Features

• IUPAC name: (6R,7R)-7-[[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-hydroxyiminoacetyl]amino]-3-ethenyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid

• Synonyms: Cefdinirum, Cefzon, CI-983, FK-482

• CAS: 91832-40-5

• Molecular formula: C14H13N5O5S2

• Molecular weight: 395.414

• Form: crystalline powder

• Color: white

• Solubility: soluble in water and slightly soluble in dilute HCL

• Brand Names
  

• Cefdinir, 

• Omnicef, 

• CFDN, 

• Cefdinirum

Cefdinir Forms and Specifications

Cefdinir is available under different specifications and forms. It is mainly available as capsules, API powder, and an oral suspension form for children. Following forms are widely available in the market.

• Cefdinir API Powder

Cefdinir API is the active pharmaceutical ingredient of the drug that is used to prepare specific formulations. It is used by all leading drug pharmaceutical companies to manufacture this antibiotic. It is available in a white, crystalline powder form online. 

• Cefdinir Capsules

Cefdinir is consumed orally in capsule form. It is available under many brand names depending on the geographical location. The capsule comes in different dosages the most common dosage used is 300 mg, reserved for chronic infections. 

Cefdinir Vs Amoxicillin

Both of these drugs are antibiotics. They are used to treat bacterial infections and belong to different classes/ Amoxicillin is a penicillin-type antibiotic whereas cefdinir is a cephalosporin. These drugs are used based on the type of infection present. Usually, cefdinir is used to treat gram-negative bacterial infections whereas amoxicillin is used to treat gram-positive bacterial infections. 

Mechanism Of Action Of Cefdinir

Cefdinir is known for its ability to fight bacterial infections that produce certain enzymes. The drug has a six-member dihydrothiazine ring compared to a five-member thiazolidine ring in penicillin. This enables it to have increased bactericidal activity and the ability to resist inactivation by those bacterial enzymes. It works by inhibiting the cell wall synthesis of the bacteria. 

Cefdinir Manufacturing Process

Cefdinir is manufactured by reacting protected thioester, 7-amino-3-vinyl-3-cephem-4-carboxylic acid, and an organic base. This is done in presence of water and a water-miscible solvent that is organic in nature. It result is protected cefdinir which is then converted into a cefdinir salt which in turn is converted into cefdinir. 

Cefdinir Uses

The antibiotic has many uses. Some of these uses include:

• Cefdinir for UTI

UTIs are urinary tract infections often caused in women due to bacterial pathogens. In uncomplicated UTIs doctors often suggest the use of cefdinir. 

• Cefdinir for Strep

Cefdinir is used to treat a variety of upper respiratory and esophageal infections including that of throat, larynx, sinuses, tonsils, and more. 

• Cefdinir for Ear Infection

FDA has approved the use of cefdinir to treat ear infections caused by bacterial microbes, including acute otitis media, skin and soft tissue infections. 

• Cefdinir for Sinus Infection

Sinus infections caused by bacteria may also be treated with help of this drug. This treatment is also FDA-approved. 

Cefdinir Side Effects

Like any other drug, cefdinir may also cause some side effects on consumption. Some of the side effects of cefdinir include:

• Vomiting

• Vaginal itching

• Red-colored stool

• Stomach pain

• Diarrhea

• Headaches

• Nausea

Cefdinir Market Size & Trends

Cefdinir's market size is expected to increase. Previously, it was seen that this antibiotic was the most sold antibiotic in the cephalosporin group in America as well. Its market revenue share percentage was 6 percent in 2015, which is expected to reach 12 percent by the year 2027. 

Cefdinir API Bulk Price

Cefdinir API bulk prices can be different in different parts of the world. The average rate for cefdinir is between 300 to 500 USD per KG. 

Cefdinir Manufacturers in China

Many active pharmaceutical ingredients manufacturers interested in making formulations and drugs with active ingredient cefdinir API want it at economical rates. India and China are leading manufactures of this API in the world. If you want to have a comprehensive list of where you can find reliable suppliers, you can always find them at pharmasources.com.You can compare price, quality, and more and find an ingredient that you like with just a few clicks. 

• Amicogen (China) Biopharm Co., Ltd

The company started operations in 2007. It has garnered a lot of respect in the market as a leading manufacturer of API, intermediates, and fine chemicals used in the synthesis of different drugs and products. You can get quality cefdinir API at economical rates from Amicogen Biopharm Co. 

• Arshine Pharmaceutical Co., Ltd

Arshine Pharmaceutical from China supplies top-quality cefdinir API and other active ingredients all over the world. It manufactures chemicals used to treat both animals and humans ever since its establishment in the year 2007. They provide APIs at wholesale rates. 

• Sino Caring Pharmaceutical Development (Suzhou) Co.Ltd

The company started working in the year 2003 and is located in Chang shu China. It exports and imports quality chemicals into and out of China. It is a domestic sales platform for selling pharmaceutical APIs and formulations of many other drugs. 

FAQs

• Is Cefdinir Penicillin?

No. Cefdinir is not a penicillin. It belongs to an antibiotic class called cephalosporin, which is much more powerful in its bacterial activity than penicillin. 

• What is cefdinir 300 mg used to treat?

Cefdinir 300mg can be used to treat a variety of infections like tonsillitis, skin infection, sinusitis, pneumonia, and chronic bronchitis. 

References

1. https://pubchem.ncbi.nlm.nih.gov/compound/Omnicef#section=Toxicity

2. https://www.chemicalbook.com/ProductChemicalPropertiesCB7483101_EN.htm

3. https://patents.google.com/patent/WO2007053723A2/en

4. https://www.cognitivemarketresearch.com/pharma-%26-healthcare/cefdinir-market-report

5. http://www.amicogenchina.com/about/?2.html

6. http://www.cnarshine.com/

7. https://m.pharmasources.com/company-profile/sino-caring-pharmaceutical-development-s-userId-2179.html