PharmaSourcesJuly 13, 2021
Tag: Aminophylline , API Ingredient , ethylenediamine , theophylline
Aminophylline is a medication used for the prevention or treatment of conditions like wheezing, shortness of breath, and certain other minor and major breathing difficulties. These breathing issues can arise because of respiratory diseases and disorders like asthma, bronchitis, and emphysema. The medication is available in the form of tablets and syrup.
Aminophylline is a drug combination that contains ethylenediamine and theophylline in the ratio of 2:1.
“A relaxant medicine that makes it easier to breathe by easing constrictions in the air passage”
IUPAC name: 1, 3-dimethyl-7H-purine-2, 6-dione; ethane-1, 2-diamine
Synonyms: Phyllocontin, Theophyllamine Diaphyllin, Drafilyn, Duraphyllin, Ethylenediamine,
CAS: 317-34-0
Molecular formula: C16H24N10O4
Molecular weight: 420.43
Form: White/Yellowish granules
Solubility: Insoluble in alcohol, ether
Norphyl, Quibron-T, Uniphyl, Theo 24.
This is available in the form of white or slightly yellowish powder, the powder is used to make the tablet and syrup Aminophylline available in the market. It is highly recommended to keep the powder away from direct sunlight.
Aminophylline tablets are used for treating conditions like asthma, bronchitis, and emphysema. The dosage of these tablets differs for adults, teenagers, and children, a subtopic that we will touch later in this discussion.
The 25 mg/ml injection of Aminophylline is used for attaining relief in conditions like bronchospasm. The injection is administered slowly via the intravenous route. Administered in a single dose, the Aminophylline injection contains no antimicrobial agents.
This is another bronchodilator that is used for treating symptoms related to medical conditions like asthma, bronchitis, and emphysema.
Apart from serving as an alleviator for several respiratory issues, the Aminophylline cream is used for reducing fat around the thigh region as well.
Before we talk about the conversion, it is important to mention here that Aminophylline is a compound of another bronchodilator known as theophylline. Ethylenediamine is found in this compound as well, the ratio between Aminophylline and Ethylenediamine is 2:1. Coming towards the main subject of this section, to calculate the dose of theophylline, multiply the Aminophylline dose by a factor of 0.8. The rationale behind this multiplication is that Aminophylline contains 80% theophylline. The key assumption made here is that the oral product is completely absorbed.
As mentioned earlier, Aminophylline is a complex of two compounds i.e. theophylline and ethylenediamine. Of these, it is theophylline that contributes most to the effect produced by the Aminophylline drug. Since theophylline can relax smooth muscles, the medication is super effective in relieving the bronchial spasm. The group of muscles targeted in this case is smooth muscles of the bronchial airways.
Aminophylline is manufactured by adding a strong aqueous solution of ethylenediamine to solid theophylline that is agitated in an appropriate vessel. Here, two moles of theophylline react with one mole of ethylenediamine to produce Aminophylline. It is worth mentioning here that there are some issues annexed with this method of preparation of Aminophylline at the commercial level e.g. formation of product lumps.
Some of the conditions for which this medication can be used include acute exacerbation of chronic bronchitis (AECB), asthma, bronchial asthma, bronchospasm, chronic bronchitis, emphysema, and certain other conditions that can lead to respiratory constrictions.
For oral use in the form of tablets, the recommended dosage of Aminophylline varies for different age groups. For children above one and adults, starting with 380 mg per day is recommended. Taking medicine after every 7-8 hours is most ideal, the only thing that one needs to be mindful of is that the total dose per day must not exceed the figure of 760mg. For an older age group, this number is around 500 mg per day.
Some of the side effects associated with this medication’s usage include chest pain, irregular heartbeat, frequent vomiting, shakiness, and increased urine production.
Even though there are many trade factors involved when it comes to finding Aminophylline API price, one can guess the average price nevertheless. This number hovers around 13 USD/KG.
Below are some manufacturers who are professional in making API ingredients.
This is a pharmaceutical company that uses modern-day technologies to produce premium-grade Aminophylline API. It produces a wide variety of active pharmaceutical ingredients of various drugs but ensures that no compromise on quality is made in the manufacturing method in any case.
Another fine option that you can consider when it comes to purchasing Aminophylline API from China is Zhejiang Chemvplus Biotech Co. Ltd. The company doesn’t limit its services to Aminophylline API though, it produces premium-grade nutrients, food additives, and API of other key medications as well.
This pharma group is one of the leading manufacturers of active pharmaceutical ingredients in China, Aminophylline API is one of their specialties.
Competing in this arena since 1943, this pharmaceutical company happens to be one of the biggest manufacturing/exporting basses in the pharma field. Considered as an absolute giant in the bulk market of pharmaceuticals, this producer of Aminophylline is another option available for consideration.
This pharmaceutical company was established in 1968 and has been producing premium quality pharmaceutical ingredients since. The Aminophylline API produced by Huazhong Pharmaceutical Co. Ltd is of excellent quality and is purchased by some of the leading sellers of medication worldwide.
Craving for knowing more? At pharmasources, you can search for hundreds of suppliers and manufacturers of Aminophylline API in China, all of which are producing premium pharmaceutical grade Aminophylline active pharmaceutical agents. Learn more about their modus operandi at pharmasources.
Despite being hit by the COVID-19 pandemic, the pharmaceutical industry is reviving slowly. Because key players in this business are big pharma giants like Pfizer, one can expect exponential growth in the Aminophylline business by the year 2027.
This drug belongs to the group of medicines known as bronchodilators.
https://pubchem.ncbi.nlm.nih.gov/compound/Aminophylline#section=Depositor-Supplied-Synonyms
https://www.surreyandsussex.nhs.uk/wp-content/uploads/2013/04/UKMIi-Aminophylline-IV-to-Oral-Conversion.pdf
https://www.mayoclinic.org/drugs-supplements/aminophylline-oral-route/proper-use/drg-20073578
https://patents.google.com/patent/US2629717A/en
Contact Us
Tel: (+86) 400 610 1188
WhatsApp/Telegram/Wechat: +86 13621645194
Follow Us: