Almac Invests $830M to Expand Crystallization Capabilities

Almac Sciences has invested approximately $485 million in an automated crystallization platform to support solid form screening of polymorphs, salts and crystals in addition to crystallization of amorphous materials. A new Empyrean X-ray powder diffractometer, which allows X-ray powder diffraction analysis of samples, represents an additional $345 million investment by the company.

The ChemSpeed Swing Crystal platform automates many common crystallisation operations, which reduces overall duration for solid form screening projects, accommodates a 24/7 run schedule and allows for rapid screening of a significantly wide variety of crystallisation conditions, including where limited sample quantity is available. The platform has the capability to:

• Weigh up to eight different powdered solids from 1mg- 100g, including either amorphous or crystalline material and electrostatic powders;

• Handle up to 60 different liquids, including a range of organic solvents, acid and base solutions for volumetric dispensing from 100µL-10mL;

• Dispense into glass vials or well-plates suitable for direct analysis by X-ray powder diffraction;

• Filter slurries and provide inert atmosphere options for sensitive materials, where required; and

• Carry out a diverse range of crystallisation unit operations, including evaporation, slurry, temperature cycling, and antisolvent additions, thereby maximising the chance of nucleation / crystallization of the material.

The platform is currently set up to accommodate vials and has been selected due to its ability to be adapted, allowing the ability to facilitate well-plates in future.

“We are excited to remain at the forefront of solid form research and development by embracing automation to maximize experimental diversity and sample throughput for tailored work programs to ensure our clients receive a premier service offering,” said Jonathan Loughrey, physical sciences manager, Almac Sciences.

Tom Moody, vice president technology development and commercialization, Almac Sciences and Arran Chemical Company, said, “Almac Sciences is a cutting-edge science and technology partner and we are committed to investing in the latest equipment to best serve our clients. With the time and cost saving benefits of automation in mind, we’re delighted to announce this further investment into automating our crystallization capabilities which is modular in design enabling elements to be upgraded in the future for expanded use cases.”