Where can you find the price of Hydrocortisone API Powder and buy it in bulk?

What is Hydrocortisone? 

Hydrocortisone is a glucocorticoid used to treat inflammation, adrenal deficiencies, autoimmune disorders, endocrine disorders, and allergic reactions. It is available as both generic and brand. Common brand names include Aquacort, Cortef, Hydrocort, Anusol-HC, and Solu-Cortef.

Hydrocortisone Forms and Specifications

Hydrocortisone is available in several different forms and specifications including hydrocortisone base API powder, hydrocortisone acetate API powder, hydrocortisone butyrate API powder, hydrocortisone sodium succinate API powder, hydrocortisone cream and ointment, hydrocortisone suppositories, and hydrocortisone tablets.

Hydrocortisone Base API Powder 99%

Raw material of hydrocortisone base API (CAS number 50-23-7) is in the form of a white crystalline powder. The specification fromChinese manufacturers Zhejiang Xianju Junye Pharmaceutical Co., Ltd., Jiangsu Jiaerke Pharmaceuticals Group Corp., Ltd., and Zhejiang Xianju Xianle Pharmaceutical Co., Ltd. is 99% min.

More Hydrocortisone API Powders are Available

There are other hydrocortisone API powders available including hydrocortisone acetate API powder, hydrocortisone butyrate API powder, and hydrocortisone sodium succinate API powder.

Hydrocortisone Cream and Ointment

Hydrocortisone is available in a cream and an ointment. They are both available with a valid prescription or can be found over the counter. They come in various sizes and concentrations as identified in the chart below.

Hydrocortisone Suppositories

Hydrocortisone suppositories are only available with a valid prescription. The brand Anusol-HC and the generic hydrocortisone acetate are both available in 25 mg suppositories.

Hydrocortisone Tablets

Hydrocortisone tablets are available in brand (Cortef) and generic with a valid prescription. They come in 5 mg, 10 mg, and 20 mg strengths. 

Hydrocortisone Mechanism of Action 

According to (DrugBank,) hydrocortisone exerts its mechanism of action by binding to the glucocorticoid receptor, intervening with changes in gene expression that result in several effects downstream such as the inhibition of death and demargination of neutrophils and the inhibition of phospholipase 2, resulting in less formation of arachidonic acid derivatives. It also inhibits several inflammatory transcription factors including NF-Kappa B but promotes anti-inflammatory genes such as interleukin-10.

Hydrocortisone Manufacturing Process

The manufacturing processes of hydrocortisone API must be performed under proper quality control systems that comply with the regulations of international Good Manufacturing Practice (GMP) in order to ensure that the API is safe and high-quality. 

Hydrocortisone API is made by raw materials, or intermediates, such as cortisone acetate, cortexolone, isopropyl acetate, potassium borohydride, saponin, and semi carbazide. These raw materials undergo chemical reactions to form the active ingredient, After the chemical process is completed, impurities are removed from the active ingredient by crystallization, centrifugation, drying, filtration, milling, and/or sieving. Hydrocortisone API undergoes purification and testing in accordance with quality standards until it reaches 99% min purity specifications.

Uses of Hydrocortisone

Hydrocortisone is used for the treatment of inflammation, adrenal deficiencies, autoimmune disorders, endocrine disorders, and allergic reactions. It is also commonly used for the treatment of hemorrhoids, eczema, and diaper rash. 

Hydrocortisone Dosage

The dosage of hydrocortisone depends on the condition being treated but generally ranges from 10 mg to 320 mg orally per day in divided doses every 6 to 8 hours.               

Side Effects of Hydrocortisone

Common side effects of hydrocortisone include acne, rapid heart rate, hyperglycemia, mood changes, and increased appetite. 

Where can you find the price of Hydrocortisone API Powder and buy it in bulk?

Below are some trustworthy manufacturers in China who are professional in making API pharmaceutical ingredient.

Hydrocortisone API Manufacturers in China:

Chinese manufacturers, Zhejiang Xianju Junye Pharmaceutical Co., Ltd., Jiangsu Jiaerke Pharmaceuticals Group Corp., Ltd., and Zhejiang Xianju Xianle Pharmaceutical Co., Ltd. manufacture bulk quantities of raw material of hydrocortisone API powder 99%. If you need a price quote and certificate of analysis (COA) or a detailed specification sheet, please visit these skillful manufacturers on www.pharmasources.com. 

Zhejiang Xianju Junye Pharmaceutical Co., Ltd.

Founded in 1998, Zhejiang Xianju Junye Pharmaceutical Co. Ltd is an experienced manufacturer using advanced manufacturing technology and machinery. Their primary focus lies in the development, production, and marketing of safe, high-quality steroid hormone APIs and intermediates. They are located at Xianju County, Taizhou City, Zhejiang Province in China. For more information, visit Zhejiang Xianju Junye Pharmaceutical Co., Ltd on pharmasources.com.

Jiangsu Jiaerke Pharmaceuticals Group Corp., Ltd.

Established in 1993, Jiangsu Jiaerke Pharmaceuticals Group Corp., Ltd. has been in the professional pharmaceutical business for more than 25 years. They specialize in the manufacturing of steroid hormone products as well as other organic chemical products, occupying a certain market share with a high reputation. Jiangsu Jiaerke Pharmaceuticals Group Corp., Ltd. holds certification in Good Manufacturing Practice (GMP) and ISO 14001 approval for APIs and intermediates. For more information, visit Jiangsu Jiaerke Pharmaceuticals Group Corp., Ltd on pharmasources.com.

Zhejiang Xianju Xianle Pharmaceutical Co., Ltd.

Zhejiang Xianju Xianle Pharmaceutical Co., Ltd. was established in 1995, having gained over 25 years of pharmaceutical manufacturing experience. They are one of the top Chinese manufacturers of steroid APIs and intermediates, supplying more than 24 products of 3 main series with export right authorization. They have built themselves up as an established high-tech business. They are certified in Good Manufacturing Practice (GMP) and hold ISO 14001 approval with an intent focus on providing 

great value and service to their customers. They are located at Xianju in China. For more information, visit Zhejiang Xianju Xianle Pharmaceutical Co., Ltd. on pharmasources.com

Advantages of PharmaSources

Pharmasources.com is a professional platform, dedicated to providing the highest-quality products and suppliers for their global customers. They deliver services to 900,000+ active members across 211 countries and regions, while featuring more than 1,600,000 products in 30 major categories that span the entire pharma supply chain. Their mission is “to connect global buyers with quality suppliers and facilitate easy trade of the pharmaceutical industry” (PharmaSources).

FAQ 

How long does hydrocortisone cream take to work?

• The affected area(s) should start to look better after 3-7 days of applying the hydrocortisone cream.

How long does hydrocortisone cream last?

• Hydrocortisone cream is usually applied to the affected area(s) once or twice daily for one week. You should see an improvement within 3-7 days of treatment. Consult with your doctor before you use it longer than prescribed.

Why are hydrocortisone suppositories so expensive?

• Hydrocortisone suppositories are often prescribed and filled as a brand such as Anusol HC. Brand tends to be more expensive than generic and are not therapeutically equivalent even though they contain the same active ingredient, hydrocortisone acetate. 

References:

1. Company Profile of Jiangsu Jiaerke Pharmaceuticals Group Corp., Ltd. PharmaSources.https://www.pharmasources.com/company-profile/jiangsu-jiaerke-pharmaceuticals-group-co-userId-199.html. Accessed May 25, 2021.

2. Company Profile of Zhejiang Xianju Junye Pharmaceutical Co. Ltd. PharmaSources.

   https://www.pharmasources.com/company-profile/zhejiang-xianju-junye-pharmaceutical-co-

   userId-319.html. Accessed May 25, 2021.

3. Company Profile of Zhejiang Xianju Xianle Pharmaceutical Co. Ltd. PharmaSources.https://www.pharmasources.com/company-profile/zhejiang-xianju-xianle-pharmaceutical-co-userId-213.html. Accessed May 25, 2021.

4. Cunha, John P., DO, FACOEP. Hydrocortisone. RxList. https://www.rxlist.com/consumer_

   hydrocortisone/drugs-condition.htm. Accessed May 25, 2021.

5. Erickson, Martin A. III, RPh. Your Compounding Questions Answered. Pharmacy Times, September 2012 Oncology, Volume 79, Issue 9. Pharmacy Times. Published September 13, 2012. https://www.pharmacytimes.com/view/your-compounding-questions-answered-0912. Accessed May 25, 2021.

6. Hydrocortisone. Chemical Book. https://www.chemicalbook.com/ChemicalProductProperty_

   EN_CB9756715.htm. Accessed May 25, 2021.

7. Hydrocortisone. DrugBank. Updated May 24, 2021. https://go.drugbank.com/drugs/DB00741. Accessed May 25, 2021.

8. Hydrocortisone. GoodRx. https://www.goodrx.com/hydrocortisone. Accessed May 25, 2021.

9. Hydrocortisone Acetate. GoodRx. https://www.goodrx.com/hydrocortisone-acetate. Accessed May 25, 2021.

10. Marsh, Tori, MPH. Hydrocortisone Acetate for Hemorrhoids: How to Save. GoodRx. Published January 3, 2018. https://www.goodrx.com/blog/hydrocortisone-acetate-for-hemorrhoids-how-to-save/. Accessed May 25, 2021.

11. National Center for Biotechnology Information. "PubChem Compound Summary for CID 5754,Hydrocortisone" PubChem, https://pubchem.ncbi.nlm.nih.gov/compound/Hydrocortisone. Accessed 25 May, 2021.