americanpharmaceuticalreviewMay 28, 2021
Tag: NeoImmuneTech , NT-I7 , PML
NeoImmuneTech, Inc., a clinical-stage T cell-focused biopharmaceutical company, announced that the first patient has been dosed in the pilot study evaluating NT-I7 (efineptakin alfa), a novel long-acting human IL-7, in progressive multifocal leukoencephalopathy (PML), a rare but very aggressive, opportunistic brain infection. PML is caused by the reactivation of John Cunningham virus (JCV) in immunocompromised individuals, and there are currently no approved therapies for this illness. This investigator-initiated study is being led by Irene Cortese, M.D., of the National Institute of Neurological Disorders and Stroke (NINDS)/National Institute of Health (NIH).
“PML is a rare but devastating disease with no approved therapeutic options,” said Dr. Cortese. “By increasing the number and functionality of patients’ lymphocytes, which are critical for fighting infections, NT-I7 may hold promise to improve PML outcomes.”
PML is characterized by progressive damage of the white matter of the brain at multiple locations resulting from lytic infection of glia cells, leading to permanent damage of the affected nervous system, and in some cases can be fatal. Common conditions predisposing PML are hematologic and solid malignancies, rheumatologic disorders, primary immune deficiencies, and HIV infection.
“We are pleased to have dosed the first patient in this pilot study and evaluate NT-I7 as a potential new treatment for PML,” said NgocDiep Le, M.D., Ph.D., Executive Vice President and Chief Medical Officer of NeoImmuneTech. “Because PML tends to affect immunocompromised individuals, NT-I7 is an ideal candidate to bolster patients’ immune response and help individuals with PML to successfully overcome this rare but devastating infection.”
Contact Us
Tel: (+86) 400 610 1188
WhatsApp/Telegram/Wechat: +86 13621645194
Follow Us: