Codex DNA Releases Synthetic Genomes for Emerging SARS-CoV-2 Variants

Codex DNA announced the release of a full-length synthetic genomes for two emerging variants of the SARS-CoV-2 virus. The new genomes include the B.1.1.7 variant that initially emerged in the UK and the B.1351 variant that was first detected in South Africa. These genomes were synthesized and constructed de novo using Codex DNA’s BioXp™ 3250 system, a fully automated synthetic biology platform.

“These ‘off-the-shelf’ SARS-CoV-2 synthetic genome variants will drive the development of vaccines, therapeutics, and diagnostics for COVID-19 research. Unlike controls released by other companies, our synthetic genomes do not need additional processing steps, thus reducing time, cost, and labor that can be better focused in other parts of the discovery and development process.” said Todd R. Nelson, PhD, CEO of Codex DNA. “We believe these new tools will be key resources in the ongoing fight against COVID-19 and we are pleased to be able to deliver them so quickly to the scientific community.”

Synthetic genomes enable researchers to rapidly and safely perform their discovery and development efforts of SARS-CoV-2 and to develop breakthrough therapies and diagnostics for this pandemic-causing virus. They can also reduce or eliminate the costs and complexity of highly regulated biosecurity facilities required for studying a dangerous pathogen. As new variants spread, it is essential for researchers to rapidly design, build, and test their genomes to ensure that future experimental outcomes are directly applicable to their goals.

Together with previously released genomes, Codex DNA now offers 12 SARS-CoV-2 synthetic genomes. These new variant genomes are IVT-ready and can be activated easily using established in vitro methods for use in developing or testing monoclonal antibody therapies or vaccines against these variants. These genomes can also serve as diagnostic controls specific to the UK and South Africa variants.