TCR² Therapeutics, ElevateBio Expand TC-210 Mfg. Capacity

TCR2 Therapeutics Inc., a clinical-stage immunotherapy company developing a novel T cell therapies for cancer, has established a manufacturing partnership with ElevateBio, LLC, to leverage technical capabilities at ElevateBio BaseCamp, a cell and gene therapy manufacturing facility in Waltham, MA. The strategic partnership will focus on the production of TC-210, TCR2’s TRuC-T cell targeting advanced mesothelin-expressing cancer, to support the anticipated Phase II clinical trial.

Elevate BaseCamp was established as a center of innovation dedicated to cell and gene therapy research and development, process development and cGMP manufacturing operations, using state-of-the-art facilities designed to rapidly develop single and multi-product cell and gene therapies, regenerative medicine and immunotherapies. The BaseCamp partnership enables TCR2 Therapeutics to establish additional manufacturing capacity in the U.S., in addition to its existing Stevenage, UK, manufacturing facility, and will support the Phase II expansion portion of the TC-210 Phase I/II clinical trial once a recommended Phase II dose is defined.

“After observing meaningful tumor regression in patients at our first, and presumably suboptimal, TC-210 dose, we are pleased to announce a manufacturing partnership with ElevateBio, an innovative organization that has significant technical expertise in the cell and gene therapy field,” said Garry Menzel, Ph.D., President and Chief Executive Officer of TCR2 Therapeutics. “To date, we have successfully manufactured T cell products for all patients treated. In anticipation of expanding our Phase 1/2 clinical trial, manufacturing with ElevateBio BaseCamp will increase both our capacity and technical capabilities to meet potential demand for clinical material for larger cancer patient populations.”

“We are excited to have entered this partnership, enabling TCR2 to leverage our cell therapy expertise and state-of-the-art center of innovation to expand their manufacturing capacity as their lead TRuC-T cell targeting solid tumors advances through the clinic,” said David Hallal, Chairman and Chief Executive Officer of ElevateBio. “BaseCamp is a world-class facility designed to support the manufacturing of cutting-edge cell therapies for our portfolio companies and for selective partners with highly innovative therapies like TCR2, allowing high-quality production at scale. We look forward to working with TCR2 and enabling their vision to cure cancer patients.”