Researchers develop compound to kill gram-positive and gram-negative antibiotic-resistant superbugs

Researchers at the University of Sheffield have developed a new compound that is able to kill both gram-positive and gram-negative antibiotic-resistant bacteria.

Gram-positive and gram-negative bacteria have different cell wall structures, but the new antibiotic compound is able to pass through the cell wall of both forms of bacteria and then bind to the DNA.

The findings, published in Chemical Science, pave the way for developing new treatments for all kinds of antibiotic-resistant bacteria, including the gram-positive MRSA and gram-negative E.Coli.

The team from the University of Sheffield has previously developed new compound leads that specifically target gram-negative bacteria, but this new compound is a broad-spectrum antimicrobial which means it is just as effective in both types of bacteria.

Gram-negative bacteria strains are particularly difficult to treat as their cell wall prevents drugs from getting into the microbe, they can cause infections including pneumonia, urinary tract infections and bloodstream infections.

The team worked with colleagues at the Science and Technology Facilities Council’s (STFC) Rutherford Appleton Laboratory (RAL).

Professor Jim Thomas, Principal Investigator of the research from the University of Sheffield, said, “Antimicrobial resistance is an increasing problem with many studies predicting a medical global emergency, so broad-spectrum antimicrobials which work against resistant pathogens are urgently needed. As the compound is luminescent it glows when exposed to light. This means we were able to follow the uptake and effect on bacteria using advanced microscopy techniques available at STFC’s Rutherford Appleton Lab.”

Doctors have not had a new treatment for gram-negative bacteria in the last 50 years, and no potential drugs have entered clinical trials since 2010.