Moderate Physical Activity Tied to Lower Fasting GLP-1 in Men

For overweight men, physical activity (PA) even at moderate intensity is associated with lower fasting and greater glucose-stimulated glucagon-like peptide-1 (GLP-1) responses, according to a study published online in Endocrine Connections.

Charlotte Janus, from the University of Copenhagen in Denmark, and colleagues conducted a cross-sectional analysis of habitual PA levels and GLP-1 concentrations in 1,326 overweight individuals. Validated radioimmunoassays were used to measure fasting and oral glucose-stimulated responses of GLP-1. Seven-day accelerometry was used to calculate PA parameters, and energy expenditure and cardiorespiratory fitness were assessed.

The researchers found that GLP-1 concentrations were 19.5 percent lower for every hour of moderate PA performed in 703 men. There were associations noted for higher cardiorespiratory fitness and PA energy expenditure with lower fasting GLP-1. Glucose-stimulated GLP-1 responses were 15.8 to 20.0 percent greater for every hour of moderate PA performed. In women, there were no correlations observed. Men spent 32 minutes/day at moderate PA on average compared with 22 minutes/day for women.

"This indicates a beneficial effect of increasing time spent on even very moderate habitual physical activity on GLP-1 secretion, thereby improving glucose regulation and potential risk of type 2 diabetes," the authors write. "Future mechanistic studies are needed to explore the potential molecular mechanism(s) underlying how habitual physical activity may affect fasting and glucose-induced GLP-1 secretion in humans."

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