Hematological Malignancy Risk Up for First-Degree Relatives

First-degree relatives of patients with hematological malignancies have increased relative risks for the same tumor types and some different hematological malignancies, according to a study published online in Blood.

Amit Sud, M.B.Ch.B., Ph.D., from the Institute of Cancer Research in London, and colleagues examined the familial risk of different hematological malignancies and their possible inter-relationships using data on more than 16 million individuals from the Swedish Family Cancer Database. Familial relative risks (FRRs) were quantified by calculating standardized incident ratios (SIRs) for the 391,131 first-degree relatives of 153,115 patients diagnosed with a primary hematological malignancy.

The researchers found that most hematological malignancies showed increased FRRs for the same tumor type, with the highest FRRs for mixed cellularity Hodgkin lymphoma, lymphoblastic lymphoma, and mantle cell lymphoma (SIRs, 16.7, 15.8, and 13.3, respectively). Evidence was seen for pleiotropic relationships, notably correlations for chronic lymphocytic leukemia with elevated familial risk of other B cell tumors and myeloproliferative neoplasms.

"These results have the potential to assist in the management of patients with hematological malignancy and their relatives and to inform future studies investigating the etiological basis of these hematological malignancies," the authors write.

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