Nosopharm, Evotec to Develop Novel Antibiotics

Nosopharm and Evotec SE have entered a partnership aimed at advancing Nosopharm’s lead candidate, NOSO-502, to the clinical stage, as well as developing a second-generation Odilorhabdin drug candidate. 

NOSO-502 is the first clinical candidate in the novel antibiotic class called Odilhorhabdins (ODLs). NOSO-502 has proven to be effective in vivo in Enterobacteriaceae infection models and demonstrated antibacterial activity in vitro against multi-drug resistant clinical isolates (KPC, NDM and OXA among others).

The second program will develop a second-generation Odilorhabdin clinical drug candidate for the treatment of hospital-acquired pneumonia and ventilation-associated pneumonia (HAP/VAP), under the name NOSO-2G. 

"We are delighted to see that such a renowned industrial biotech partner has decided to support the development of our new class of antibiotics," said Philippe Villain-Guillot, co-founder and chief executive officer of Nosopharm. "We are very much looking forward to advancing our first drug candidate into the clinic and to expanding our drug development to a second candidate."

"It’s exciting to see the development of an entirely new antibiotic class, which is crucial in these times of rising antibiotic resistance," said Dr Cord Dohrmann, chief scientific officer at Evotec. "We are thrilled to play a key role in this partnership and we believe that with the unique combination of our infectious disease expertise and drug discovery and early development platforms, the lead candidates will soon enter the clinic and bring hope to physicians and their patients living with nosocomial infections caused by multidrug-resistant bacteria."

Nosopharm expects CTA-filing to take place in 2021 and to launch first-in-human studies with NOSO-502 in 2021. The clinical candidate selection process for NOSO-2G is expected in 2022.

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