Adverse Outcomes Up for Pregnant Women With Migraine

Pregnant women with migraine and their offspring have increased risks of several adverse pregnancy and neonatal outcomes, according to a study recently published in Headache.

Nils Skajaa, from Aarhus University Hospital in Denmark, and colleagues used Danish population registries to assemble a cohort of pregnancies among women with migraine (22,841 pregnancies) and an age- and conception year-matched cohort of pregnancies among women without migraine (228,324 pregnancies). The correlations between maternal migraine and adverse pregnancy, neonatal, and postnatal outcomes in mothers and offspring were examined.

The researchers found that migraine correlated with increased risk of pregnancy-associated hypertension disorders and miscarriage. There were also associations for migraine with increased prevalence of low birth weight, preterm birth, and cesarean delivery; no correlations were seen for small for gestational age offspring or birth defects. Elevated risks of several outcomes were seen in the neonatal and postnatal period for offspring prenatally exposed to maternal migraine, including intensive care unit admission, hospitalization, dispensed prescriptions, respiratory distress syndrome, and febrile seizures; no correlations were seen for death or cerebral palsy.

"Our findings suggest that migraine itself, rather than its treatment, is associated with adverse outcomes," the authors write.

Two authors disclosed financial ties to Amgen, which funded the study.

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