Colonoscopy Quality Not Affected by Sedation Method

Among patients at average risk undergoing screening colonoscopies, there is no benefit associated with deep sedation versus moderate sedation, according to a study recently published in Gastrointestinal Endoscopy.

Erica P. Turse, D.O., M.P.H., from the University of Missouri School of Medicine in Columbia, and colleagues assessed whether sedation level affected the outcomes of adenoma detection rate (ADR) or polyp detection rate (PDR) among 585 healthy, average-risk patients who underwent index screening colonoscopy at a single institution. Patients underwent either moderate sedation only (June 1, 2015, to Dec. 31, 2015; 57.7 percent of the study cohort) or deep sedation only (June 1, 2016, to Dec. 31, 2016; 42.2 percent of the study cohort).

The researchers found an overall PDR of 70.1 percent and an ADR of 41.7 percent. There were no significant differences between the groups for ADR (44.1 versus 38.5 percent; P = 0.18) or PDR (71.9 versus 67.6 percent; P = 0.27). Similarly, when analyzed by gender within each sedation group, there were no significant differences in PDR or ADR between the groups.

"If we found a significant improvement in detection with moderate sedation compared to deep sedation, then we may consider going back to moderate sedation," a coauthor said in a statement. "But since we didn't really find a difference, I think the efficiency factor of deep sedation wins out."

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