Undetected Dysglycemia Linked to MI, Periodontal Disease

Undetected dysglycemia is associated with both myocardial infarction (MI) and periodontitis (PD), according to a study published online in Diabetes Care.

Anna Norhammar, M.D., from the Karolinska Institutet in Stockholm, and colleagues examined associations between undetected dysglycemia and MI and PD in a study including 805 patients with a first MI and 805 matched controls. Periodontal status was categorized as healthy, moderate, or severe.

The researchers found that abnormal glucose tolerance (AGT) was more common in patients than in controls (32 versus 19 percent) and was associated with MI (odds ratio [OR], 2.03; 95 percent confidence interval [CI], 1.58 to 2.60). Undetected diabetes correlated with severe PD (OR, 2.50; 95 percent CI, 1.36 to 4.63), which was stronger in patients (OR, 2.35; 95 percent CI, 1.15 to 4.80) than in controls (OR, 1.80, 95 percent CI, 0.48 to 6.78). This correlation was not seen when categorized as AGT (total cohort, OR, 1.07; 95 percent CI, 0.67 to 1.72). Severe PD was most common in those with undetected diabetes, and undetected diabetes was most common in severe PD.

"The findings support the hypothesis that dysglycemia is a driver for two common diseases in the general population, MI and PD, thereby highlighting the impact that such disturbances might have on health care demands," the authors write.

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