Type 2 Diabetes Risk Lower in Women With Active Migraine

Women with active migraine have a lower risk for type 2 diabetes, according to a study published online Dec. 17 in JAMA Neurology.

Guy Fagherazzi, Ph.D., from the Institut National de la Santé et de la Recherche Médicale in Villejuif, France, and colleagues evaluated data from a prospective population-based study involving a cohort of 98,995 women born between 1925 to 1950. A total of 76,403 women completed the 2002 follow-up questionnaire and had information available on migraine. The final sample of women underwent follow-up during 2004 to 2014; 74,247 were included in the study after 2,156 with type 2 diabetes were excluded.

There were 2,372 incident type 2 diabetes cases during 10 years of follow-up. The researchers found that compared with women with no migraine history, those with active migraine had a lower risk for type 2 diabetes (univariate hazard ratio, 0.80; multivariable-adjusted hazard ratio, 0.70). During the 24 years prior to diabetes diagnosis, after adjustment for potential type 2 diabetes risk factors, there was a linear decrease in active migraine prevalence from 22 to 11 percent. For 22 years after diagnosis, the prevalence of migraine plateaued around 11 percent.

"These results can have substantial implications on the understanding of mechanisms underlying these two conditions," the authors write.

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