NVP015 Program Accelerated Through Research Grant to CHOP

NeuroVive Pharmaceutical announced scientists at the company's research partner the Children's Hospital of Philadelphia (CHOP) have received a three-year grant (W81XWH-17-PRMRP-TTDA), in total of $4,090,281 USD, from the U.S. Department of Defense, Office of the Congressionally Directed Medical Research Programs (CDMRP) for studies focused on NeuroVive's NVP015 program for genetic mitochondrial diseases.

The program evaluating preclinical efficacy and exploring viable future clinical endpoints for the NVP015 program, will be conducted by a team of experts under the leadership of Principal Investigator Dr. Todd Kilbaugh, Associate Professor of Anesthesiology, Critical Care and Pediatrics. The objective of the therapeutic development program is to develop a drug candidate for Investigational New Drug (IND) submission to the Food and Drug Administration (FDA) for initiation of Phase I clinical trials.

"We are delighted by the news that our research partners at CHOP are receiving this grant. It further validates the extensive interest our novel succinate prodrug approach to treating mitochondrial diseases has generated. The grant will allow Dr. Kilbaugh and his team to thoroughly explore the therapeutic potential of our succinate prodrug compounds and advance them towards a novel treatment for acute energy crises in patients with genetic mitochondrial diseases for which there currently are only symptomatic treatment options available. The outcomes of the grant will expedite the development of our NVP015 project into first in man studies," said NeuroVive Chief Scientific Officer Dr. Eskil Elmér.

The team of experts at CHOP include co-investigators Professor Douglas C Wallace, Director of the Center for Mitochondrial and Epigenomic Medicine (CMEM), Dr. Marni J Falk, Executive Director of Mitochondrial Medicine, and NeuroVive affiliated Dr. Michael Karlsson. In addition, NeuroVive Chief Scientific Officer Dr. Eskil Elmér and NeuroVive Senior Scientist Dr. Johannes Ehinger are formal consultants to the project.

The studies under the grant from the U.S. Department of Defense CDMRP will be the third, and most extensive, collaboration between NeuroVive and CHOP. The first ongoing NVP015 research collaboration is focused on genetic mitochondrial diseases, headed by Dr. Marni J Falk. The second on the use of NVP015 to mitigate the health effects of toxic chemicals, including traditional chemical warfare agents, toxic industrial chemicals and pesticides, headed by Dr. Todd Kilbaugh and funded by the NIH CounterACT program.

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