NIH-funded study reverses congenital blindness in mice

A study funded by the National Institutes of Health’s (NIH) National Eye Institute (NEI) has successfully reversed congenital blindness by changing the supportive Müller glia cells in the retina into rod photoreceptors.

Conducted in mice, the research is expected to help in advancing regenerative therapies for the treatment of blinding diseases, such as retinitis pigmentosa.

Photoreceptors are light-sensitive cells in the retina that signal the brain upon activation. In mammals, including humans, photoreceptors cannot regenerate on their own.

NEI retinal neuroscience programme director Thomas Greenwell said: "Rods allow us to see in low light, but they may also help preserve cone photoreceptors, which are important for colour vision and high visual acuity. Cones tend to die in later-stage eye diseases.

"If rods can be regenerated from inside the eye, this might be a strategy for treating diseases of the eye that affect photoreceptors."

During the initial phase of the study, the researchers injected a gene for activating the beta-catenin protein in order to trigger Müller glia in normal mice.

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