europeanpharmaceuticalreviewJuly 30, 2018
The webinar will describe how 2D NMR can offer protein biochemists unprecedented analytical precision. By assigning just one spectrum, users can obtain a unique fingerprint of a protein at an atomistic resolution. This non-destructive technique can also be combined with other complimentary techniques to gain even further insights into sample quality.
Examples of the spectral processing and statistical and chemometric analysis methods being developed to increase automation will also be described. Aside from enabling simultaneous analysis of large data volumes, the automation available today has almost advanced to the point that even non-experts will be able to acquire and analyse NMR spectra for decision making.
You will also learn:
2D NMR spectral fingerprinting for higher order structure analysis of biologics
Application to biologics in their formulated state for structural assessment
Benefits of the advances in automated data acquisition and analysis
Reproducibility and robustness for inter-lab precision
Practical, easy application of 2D NMR in the biopharma spa
Bruker’s latest instrumentation and software for 2D NMR analysis
2D NMR spectral fingerprinting for higher order structure analysis of biologics
Application to biologics in their formulated state for structural assessment
Benefits of the advances in automated data acquisition and analysis
Reproducibility and robustness for inter-lab precision
Practical, easy application of 2D NMR in the biopharma space
Bruker’s latest instrumentation and software for 2D NMR analysis
Keynote Speakers
John P. Marino, Leader, Biomolecular Structure & Function Group – NIST
Associate Director, Institute for Bioscience and Biotechnology Research
National Institute of Standards and Technology & University of Maryland
Since 2008, Dr. Marino has been the leader of the NIST Biomolecular Structure & Function Group and Associate Director of the Institute for Bioscience and Biotechnology Research (IBBR), a joint research institute of the University of Maryland and NIST, in Rockville, Maryland.
Dr. Marino joined NIST in 1997 as a Research Chemist and was appointed Adjunct Professor at the University of Maryland. Prior to coming to NIST, Dr. Marino completed a Ph.D. in Chemistry from Yale University in 1995 and a two year postdoc at the Goethe Universität in Frankfurt, Germany as an Alexander von Humboldt fellow. Dr. Marino’s research interests are primarily focused on developing Nuclear Magnetic Resonance (NMR) methods to advance precision measurement of biomolecular structure and dynamics, with his most recent work focused on the development of techniques for assessment of the higher-order-structure (HOS) of biotherapeutics.
Jason S. Wood, Ph.D. Americas Market Manager – Pharma/Biotech
With a Ph.D. in Bio-organic Chemistry (University of Buffalo) and a post-doctoral fellowship at the National Institutes of Health (NIA), Dr. Wood spent a number of years in the biopharmaceutical industry before becoming the Global Product Line Manager of Quadrupole Mass Spectrometry at Varian Inc. Subsequently, Dr. Wood became Senior Product Manager of Bio IC at Dionex Corp (now Thermo Fisher Scientific), where is successfully released and managed the world’s first capillary ion chromatography system, the ICS-5000. Dr. Wood is currently the Regional Market Manager (Americas) at Bruker BioSpin where he manages marketing in the pharma and biotech space.
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