Natrecor (nesiritide; Johnson & Johnson) Drug Analysis 2018

Natrecor (nesiritide; Johnson & Johnson) is a recombinant form of human brain natriuretic peptide (BNP), a circulating hormone of cardiac origin indicated for the treatment of patients with acute decompensated heart failure (ADHF) who have dyspnea at rest or with minimal activity. BNP is naturally secreted by the ventricular myocardium in response to volume overload and increased filling pressure. It binds to the particulate guanylate cyclase receptor of vascular smooth muscle and endothelial cells, leading to increased intracellular concentrations of guanosine 3'5'-cyclic monophosphate (cGMP) and smooth muscle cell relaxation.

cGMP serves as a second messenger to dilate veins and arteries, and Natrecor causes natriuresis and a reduction in intravascular volume. The natriuretic effect results from a direct inhibition of sodium absorption in the renal collecting duct, increased glomerular infiltration, and inhibited aldosterone production and secretion. This produces a prompt fall in systemic vascular resistance and pulmonary capillary wedge pressure, associated with rapid clinical improvement in ADHF.

Key Topics Covered:

1 Product Profiles

Natrecor: Acute decompensated heart failure (ADHF)

List of Figures

Figure 1: Natrecor for ADHF - SWOT analysis

Figure 2: The author's drug assessment summary for Natrecor in ADHF

Figure 3: The author's drug assessment summary for Natrecor in ADHF

List of Tables

Table 1: Natrecor drug profile

Table 2: Natrecor Phase III data in ADHF

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