Arena Pharmaceuticals Provides Corporate Update and Reports Fourth Quarter and Full-Year 2017 Financ

 Arena Pharmaceuticals, Inc. (NASDAQ: ARNA), today provided a corporate update and reported financial results for the fourth quarter and full-year ended December 31, 2017.

"We've made significant progress in 2017, achieving the clinical and corporate objectives we set forth as a new team," said Amit D. Munshi, president and CEO of Arena. "Our focus remains on advancing our potentially best-in-class or best-in-disease pipeline and driving further value in the Company. We look forward to the etrasimod Phase 2 data readout this month and are enthusiastic about the Phase 3 clinical program for ralinepag, which we expect to begin in the second half of 2018."

Pipeline Update

Ralinepag - Oral, next generation, selective prostacyclin receptor agonist intended for the treatment of pulmonary arterial hypertension (PAH)

• Phase 3 clinical program preparations continue to progress
• Expect to initiate three studies within the Phase 3 clinical program in H2 2018

Etrasimod - Oral, next generation, selective sphingosine-1-phosphate (S1P) receptor modulator intended for the potential treatment of multiple immune and inflammatory diseases

• Ulcerative colitis (UC):
  • Phase 2 data expected March 2018
• Primary biliary cholangitis (PBC):
  • Phase 2 trial currently enrolling patients
• Pyoderma gangrenosum (PG):
  • Phase 2 trial currently enrolling patients

APD371 - Oral, peripherally restricted, full agonist of the cannabinoid 2 (CB2) receptor intended for the potential treatment of visceral pain, specifically pain associated with Crohn's disease

• Phase 2 trial currently enrolling patients
• Data expected Q2 2018

Collaborations Update

• Everest Medicines Limited (Everest) partnership
  • In December, Arena entered into a development and commercialization partnership with Everest, a C-Bridge Capital-backed biopharmaceutical company focused on developing and commercializing innovative pharmaceutical products in China, for ralinepag and etrasimod in mainland China, Taiwan, China, Hong Kong, S.A.R., China, Macau, S.A.R., China, and South Korea.
  • Arena received an upfront payment of $12.0 million, is eligible to receive up to $212.0 million in development and commercial milestone payments, and is entitled to receive up to low double-digit royalties on future net annual sales of both ralinepag and etrasimod.

Corporate Update

• On March 9, 2018 we entered into an Asset Purchase Agreement for the sale of our manufacturing operations located in Zofingen, Switzerland, to Siegfried. The transaction is expected to close on or about March 31, 2018.

Financial Update

Fourth Quarter 2017 Financial Results

• Revenues totaled $15.4 million, consisting of $14.2 million in collaboration revenue, and $1.2 million in royalty revenue from Eisai. Included in the collaboration revenue is the $12.0 million upfront fee Arena received from Everest in connection with the development and commercialization partnership.
• Research and development expenses totaled $20.7 million
• General and administrative expenses totaled $8.3 million
• Net loss attributable to stockholders of Arena was $13.7 million, or $0.35 per share

Full-Year 2017 Financial Results

• Revenues totaled $21.3 million, consisting of $19.6 million in collaboration revenue, and $1.7 million in royalty revenue from Eisai. Included in the collaboration revenue is the $12.0 million upfront fee Arena received from Everest in connection with the development and commercialization partnership, and approximately $7.3 million of revenue from the Boehringer Ingelheim and Axovant collaborations.
• Research and development expenses totaled $71.0 million
• General and administrative expenses totaled $30.3 million
• Litigation settlement expense, net related to the tentative settlement of the 2010 securities class action litigation totaled $12.0 million
• Discontinued operations income of $3.1 million includes all revenues and expenses associated with our manufacturing operations that are classified as held-for-sale as a result of our planned divestiture of the Zofingen facility
• Net loss attributable to stockholders of Arena was $91.4 million, or $2.77 per share

At December 31, 2017, the Company's cash, cash equivalents and investments balance was $271.3 million and approximately 39.3 million shares of Arena common stock were outstanding.

Conference Call & Webcast Information
The Company will host a conference call and live webcast with the investment community today, Wednesday, March 14, 2018, at 8:30 a.m. EDT to discuss the financial results and provide a corporate update.

When: March 14, 2018, 8:30 a.m. EDT
Dial-in: (877) 643-7155 (United States) or (914) 495-8552 (International)
Conference ID: 2074279

Please join the conference call at least 10 minutes early to register. You can access the live webcast under the investor relations section of Arena's website at: www.arenapharm.com. A replay of the conference call will be archived under the investor relations section of Arena's website for 30 days shortly after the call.

About Arena Pharmaceuticals 
Arena Pharmaceuticals is focused on developing novel, small molecule drugs with optimized receptor pharmacology and pharmacokinetics designed to deliver broad clinical utility across several therapeutic areas. Arena's proprietary pipeline includes potentially first- or best-in-class programs. The most advanced investigational clinical programs are ralinepag (APD811), which will be commencing a Phase 3 program for pulmonary arterial hypertension (PAH), and etrasimod (APD334), which is in Phase 2 for a broad range of immune and inflammatory conditions. Arena is also evaluating APD371 in Phase 2 for the treatment of pain associated with Crohn's disease. In addition, Arena has collaborations with the following pharmaceutical companies: Everest Medicines Limited (ralinepag and etrasimod in Greater China and select Asian countries), Axovant Sciences GmbH (nelotanserin - Phase 2), Boehringer Ingelheim International GmbH (undisclosed target - preclinical), and Eisai Co., Ltd. and Eisai Inc. (BELVIQ^®- marketed product).

Forward-Looking Statements 
Certain statements in this press release are forward-looking statements that involve a number of risks and uncertainties. Such forward-looking statements may be identified by words such as "anticipated," "focus," "potential," "look forward to," "expect," "intended for," "entitled to," "planned," "designed to," and "will," and include, without limitation, statements about initiation, enrollment, results, data readouts and timing relating to ongoing and intended clinical trials; the potential of Arena's drug candidates; the planned sale of Arena's manufacturing operations in Zofingen, Switzerland; Arena's investment community conference call and webcast; and Arena's focus, goals, strategy, clinical programs, and collaborators. For such statements, Arena claims the protection of the Private Securities Litigation Reform Act of 1995. Actual events or results may differ materially from Arena's expectations. Factors that could cause actual results to differ materially from the forward-looking statements include, but are not limited to, the following: the risk that we may need additional funds to advance all of our programs, and you and others may not agree with the manner we allocate our resources; risks related to developing and commercializing drugs; risks and uncertainties relating to cash and revenues that may be generated from product sales or other sources, including the impact of competition; the risk that Arena's revenues are based in part on estimates, judgment and accounting policies, and incorrect estimates or disagreement regarding estimates or accounting policies may result in changes to Arena's guidance or previously reported results; the timing and outcome of research, development and regulatory review is uncertain, and our drug candidates may not advance in development or be approved for marketing; enrolling patients in our ongoing and intended clinical trials is competitive and challenging; clinical trials and other studies may not proceed at the time or in the manner expected or at all; unexpected or unfavorable new data; nonclinical and clinical data is voluminous and detailed, and regulatory agencies may interpret or weigh the importance of data differently and reach different conclusions than Arena or others, request additional information, have additional recommendations or change their guidance or requirements before or after approval; results of clinical trials and other studies are subject to different interpretations and may not be predictive of future results; topline data may not accurately reflect the complete results of a particular study or trial; satisfactory resolution of litigation or other disagreements with others; government and third-party payor actions, including relating to reimbursement and pricing; risks related to relying on collaborative arrangements; the entry into or modification or termination of collaborative arrangements; and Arena's and third parties' intellectual property rights. Additional factors that could cause actual results to differ materially from those stated or implied by Arena's forward-looking statements are disclosed in Arena's filings with the Securities and Exchange Commission. These forward-looking statements represent Arena's judgment as of the time of this release. Arena disclaims any intent or obligation to update these forward-looking statements, other than as may be required under applicable law.

 Arena Pharmaceuticals, Inc. (NASDAQ: ARNA), today provided a corporate update and reported financial results for the fourth quarter and full-year ended December 31, 2017.

"We've made significant progress in 2017, achieving the clinical and corporate objectives we set forth as a new team," said Amit D. Munshi, president and CEO of Arena. "Our focus remains on advancing our potentially best-in-class or best-in-disease pipeline and driving further value in the Company. We look forward to the etrasimod Phase 2 data readout this month and are enthusiastic about the Phase 3 clinical program for ralinepag, which we expect to begin in the second half of 2018."

Pipeline Update

Ralinepag - Oral, next generation, selective prostacyclin receptor agonist intended for the treatment of pulmonary arterial hypertension (PAH)

Phase 3 clinical program preparations continue to progress

Expect to initiate three studies within the Phase 3 clinical program in H2 2018

Etrasimod - Oral, next generation, selective sphingosine-1-phosphate (S1P) receptor modulator intended for the potential treatment of multiple immune and inflammatory diseases

Ulcerative colitis (UC):

Phase 2 data expected March 2018

Primary biliary cholangitis (PBC):

Phase 2 trial currently enrolling patients

Pyoderma gangrenosum (PG):

Phase 2 trial currently enrolling patients

APD371 - Oral, peripherally restricted, full agonist of the cannabinoid 2 (CB2) receptor intended for the potential treatment of visceral pain, specifically pain associated with Crohn's disease

Phase 2 trial currently enrolling patients

Data expected Q2 2018

Collaborations Update

Everest Medicines Limited (Everest) partnership

In December, Arena entered into a development and commercialization partnership with Everest, a C-Bridge Capital-backed biopharmaceutical company focused on developing and commercializing innovative pharmaceutical products in China, for ralinepag and etrasimod in mainland China, Taiwan, China, Hong Kong, S.A.R., China, Macau, S.A.R., China, and South Korea.

Arena received an upfront payment of $12.0 million, is eligible to receive up to $212.0 million in development and commercial milestone payments, and is entitled to receive up to low double-digit royalties on future net annual sales of both ralinepag and etrasimod.

Corporate Update

On March 9, 2018 we entered into an Asset Purchase Agreement for the sale of our manufacturing operations located in Zofingen, Switzerland, to Siegfried. The transaction is expected to close on or about March 31, 2018.

Financial Update

Fourth Quarter 2017 Financial Results

Revenues totaled $15.4 million, consisting of $14.2 million in collaboration revenue, and $1.2 million in royalty revenue from Eisai. Included in the collaboration revenue is the $12.0 million upfront fee Arena received from Everest in connection with the development and commercialization partnership.

Research and development expenses totaled $20.7 million

General and administrative expenses totaled $8.3 million

Net loss attributable to stockholders of Arena was $13.7 million, or $0.35 per share

Full-Year 2017 Financial Results

Revenues totaled $21.3 million, consisting of $19.6 million in collaboration revenue, and $1.7 million in royalty revenue from Eisai. Included in the collaboration revenue is the $12.0 million upfront fee Arena received from Everest in connection with the development and commercialization partnership, and approximately $7.3 million of revenue from the Boehringer Ingelheim and Axovant collaborations.

Research and development expenses totaled $71.0 million

General and administrative expenses totaled $30.3 million

Litigation settlement expense, net related to the tentative settlement of the 2010 securities class action litigation totaled $12.0 million

Discontinued operations income of $3.1 million includes all revenues and expenses associated with our manufacturing operations that are classified as held-for-sale as a result of our planned divestiture of the Zofingen facility

Net loss attributable to stockholders of Arena was $91.4 million, or $2.77 per share

At December 31, 2017, the Company's cash, cash equivalents and investments balance was $271.3 million and approximately 39.3 million shares of Arena common stock were outstanding.

Conference Call & Webcast Information
The Company will host a conference call and live webcast with the investment community today, Wednesday, March 14, 2018, at 8:30 a.m. EDT to discuss the financial results and provide a corporate update.

When: March 14, 2018, 8:30 a.m. EDT
Dial-in: (877) 643-7155 (United States) or (914) 495-8552 (International)
Conference ID: 2074279

Please join the conference call at least 10 minutes early to register. You can access the live webcast under the investor relations section of Arena's website at: www.arenapharm.com. A replay of the conference call will be archived under the investor relations section of Arena's website for 30 days shortly after the call.

About Arena Pharmaceuticals 
Arena Pharmaceuticals is focused on developing novel, small molecule drugs with optimized receptor pharmacology and pharmacokinetics designed to deliver broad clinical utility across several therapeutic areas. Arena's proprietary pipeline includes potentially first- or best-in-class programs. The most advanced investigational clinical programs are ralinepag (APD811), which will be commencing a Phase 3 program for pulmonary arterial hypertension (PAH), and etrasimod (APD334), which is in Phase 2 for a broad range of immune and inflammatory conditions. Arena is also evaluating APD371 in Phase 2 for the treatment of pain associated with Crohn's disease. In addition, Arena has collaborations with the following pharmaceutical companies: Everest Medicines Limited (ralinepag and etrasimod in Greater China and select Asian countries), Axovant Sciences GmbH (nelotanserin - Phase 2), Boehringer Ingelheim International GmbH (undisclosed target - preclinical), and Eisai Co., Ltd. and Eisai Inc. (BELVIQ®- marketed product).

Forward-Looking Statements 
Certain statements in this press release are forward-looking statements that involve a number of risks and uncertainties. Such forward-looking statements may be identified by words such as "anticipated," "focus," "potential," "look forward to," "expect," "intended for," "entitled to," "planned," "designed to," and "will," and include, without limitation, statements about initiation, enrollment, results, data readouts and timing relating to ongoing and intended clinical trials; the potential of Arena's drug candidates; the planned sale of Arena's manufacturing operations in Zofingen, Switzerland; Arena's investment community conference call and webcast; and Arena's focus, goals, strategy, clinical programs, and collaborators. For such statements, Arena claims the protection of the Private Securities Litigation Reform Act of 1995. Actual events or results may differ materially from Arena's expectations. Factors that could cause actual results to differ materially from the forward-looking statements include, but are not limited to, the following: the risk that we may need additional funds to advance all of our programs, and you and others may not agree with the manner we allocate our resources; risks related to developing and commercializing drugs; risks and uncertainties relating to cash and revenues that may be generated from product sales or other sources, including the impact of competition; the risk that Arena's revenues are based in part on estimates, judgment and accounting policies, and incorrect estimates or disagreement regarding estimates or accounting policies may result in changes to Arena's guidance or previously reported results; the timing and outcome of research, development and regulatory review is uncertain, and our drug candidates may not advance in development or be approved for marketing; enrolling patients in our ongoing and intended clinical trials is competitive and challenging; clinical trials and other studies may not proceed at the time or in the manner expected or at all; unexpected or unfavorable new data; nonclinical and clinical data is voluminous and detailed, and regulatory agencies may interpret or weigh the importance of data differently and reach different conclusions than Arena or others, request additional information, have additional recommendations or change their guidance or requirements before or after approval; results of clinical trials and other studies are subject to different interpretations and may not be predictive of future results; topline data may not accurately reflect the complete results of a particular study or trial; satisfactory resolution of litigation or other disagreements with others; government and third-party payor actions, including relating to reimbursement and pricing; risks related to relying on collaborative arrangements; the entry into or modification or termination of collaborative arrangements; and Arena's and third parties' intellectual property rights. Additional factors that could cause actual results to differ materially from those stated or implied by Arena's forward-looking statements are disclosed in Arena's filings with the Securities and Exchange Commission. These forward-looking statements represent Arena's judgment as of the time of this release. Arena disclaims any intent or obligation to update these forward-looking statements, other than as may be required under applicable law.

Arena Pharmaceuticals, Inc. Condensed Consolidated Statements of Operations (In thousands, except per share amounts) Three months ended Year ended December 31, December 31, ------------ ------------ 2017 2016 2017 2016 ---- ---- ---- ---- (unaudited) Revenues Collaboration and other revenue $14,193 $69,225 $19,632 $92,163 Royalty revenue 1,171 - 1,705 - ----- --- ----- --- Total revenues 15,364 69,225 21,337 92,163 Operating Costs & Expenses Research & development 20,711 11,567 70,988 63,782 General & administrative 8,253 6,981 30,341 27,529 Litigation settlement expense, net - - 11,975 - Restructuring charges - - - 6,115 --- --- --- ----- Total operating costs & expenses 28,964 18,548 113,304 97,426 Total interest & other expense, net (670) (1,751) (3,887) (7,037) ---- ------ ------ ------ Income (loss) from continuing operations (14,270) 48,926 (95,854) (12,300) Income (loss) from discontinued operations 315 (10,612) 3,122 (10,596) --- ------- ----- ------- Net income (loss) (13,955) 38,314 (92,732) (22,896) ======= ====== ======= ======= Less net loss attributable to noncontrolling interest in consolidated variable interest entity 271 258 1,325 380 --- --- ----- --- Net (income) loss attributable to stockholders of Arena $(13,684) $38,572 $(91,407) $(22,516) ======== ======= ======== ======== Amounts attributable to stockholders of Arena: Income (loss) from continuing operations (13,999) 49,184 (94,529) (11,920) Income (loss) from discontinued operations 315 (10,612) 3,122 (10,596) --- ------- ----- ------- $(13,684) $38,572 $(91,407) $(22,516) ======== ======= ======== ======== Net income (loss) attributable to stockholders of Arena per share, diluted:(1) Continuing operations $(0.36) $2.02 $(2.87) $(0.49) Discontinued operations 0.01 (0.43) 0.10 (0.44) ---- ----- ---- ----- $(0.35) $1.59 $(2.77) $(0.93) ====== ===== ====== ====== Net income (loss) attributable to stockholders of Arena per share, diluted:(1) Continuing operations $(0.36) $2.02 $(2.87) $(0.49) Discontinued operations 0.01 (0.44) 0.10 (0.44) ---- ----- ---- ----- $(0.35) $1.58 $(2.77) $(0.93) Shares used in calculating net loss attributable to stockholders of Arena per share, basic(1) 39,268 24,333 32,990 24,313 ====== ====== ====== ====== Shares used in calculating net loss attributable to stockholders of Arena per share, diluted(1) 39,268 24,343 32,990 24,313 ====== ====== ====== ======

(1) Comparative period data adjusted to give effect to Arena's June 2017 1-for-10 reverse stock split.

Arena Pharmaceuticals, Inc. Condensed Consolidated Balance Sheet Data (In thousands) December 31, 2017 December 31, 2016 ----------------- ----------------- 1 (1) Assets Cash & cash equivalents $158,837 $90,712 Accounts receivable 2,357 573 Insurance recovery receivable 12,025 - Prepaid expenses & other current assets 2,681 2,169 Total available for sale investments 112,482 - Land, property & equipment, net 30,131 35,109 Other non- current assets 3,622 2,841 Total assets of disposal group held for sale 17,140 37,606 ------ ------ Total assets $339,275 $169,010 ======== ======== Liabilities & Equity Accounts payable & accrued liabilities $15,622 $9,559 Accrued litigation settlement 24,000 - Total deferred revenues 2,177 6,577 Total lease financing obligations & other long- term liabilities 62,737 66,087 Total liabilities of disposal group held for sale 27,595 46,392 Total equity 207,144 40,395 ------- ------ Total liabilities & equity $339,275 $169,010 ======== ========

(1) The Condensed Consolidated Balance Sheet Data has been derived from the audited financial statements as of that date.

(Tables Follow)

 Arena Pharmaceuticals, Inc.

                                                           Condensed Consolidated Statements of Operations

                                                              (In thousands, except per share amounts)


                                                                         Three months ended                            Year ended

                                                                            December 31,                              December 31,
                                                                          ------------                           ------------

                                                                         2017                               2016                    2017        2016
                                                                         ----                               ----                    ----        ----

                                                                           (unaudited)

    Revenues

    Collaboration and other revenue                                   $14,193                            $69,225                 $19,632     $92,163

    Royalty revenue                                                     1,171                                  -                  1,705           -
                                                                        -----                                ---                  -----         ---

      Total revenues                                                   15,364                             69,225                  21,337      92,163


    Operating Costs & Expenses

    Research & development                                             20,711                             11,567                  70,988      63,782

    General & administrative                                            8,253                              6,981                  30,341      27,529

    Litigation settlement expense, net                                      -                                 -                 11,975           -

    Restructuring charges                                                   -                                 -                      -      6,115
                                                                          ---                               ---                    ---      -----

      Total operating costs & expenses                                 28,964                             18,548                 113,304      97,426


      Total interest & other expense, net                               (670)                           (1,751)                (3,887)    (7,037)
                                                                         ----                             ------                  ------      ------

    Income (loss) from continuing operations                         (14,270)                            48,926                (95,854)   (12,300)

    Income (loss) from discontinued operations                            315                           (10,612)                  3,122    (10,596)
                                                                          ---                            -------                   -----     -------

    Net income (loss)                                                (13,955)                            38,314                (92,732)   (22,896)
                                                                      =======                             ======                 =======     =======

    Less net loss attributable to
     noncontrolling interest in consolidated
     variable interest entity                                             271                                258                   1,325         380
                                                                          ---                                ---                   -----         ---

    Net (income) loss attributable to
     stockholders of Arena                                          $(13,684)                           $38,572               $(91,407)  $(22,516)
                                                                     ========                            =======                ========    ========


    Amounts attributable to stockholders of Arena:

      Income (loss) from continuing operations                       (13,999)                            49,184                (94,529)   (11,920)

      Income (loss) from discontinued operations                          315                           (10,612)                  3,122    (10,596)
                                                                          ---                            -------                   -----     -------

                                                                    $(13,684)                           $38,572               $(91,407)  $(22,516)
                                                                     ========                            =======                ========    ========


    Net income (loss) attributable to
     stockholders of Arena per share,
     diluted:(1)

       Continuing operations                                          $(0.36)                             $2.02                 $(2.87)    $(0.49)

       Discontinued operations                                           0.01                             (0.43)                   0.10      (0.44)
                                                                         ----                              -----                    ----       -----

                                                                      $(0.35)                             $1.59                 $(2.77)    $(0.93)
                                                                       ======                              =====                  ======      ======


    Net income (loss) attributable to stockholders of Arena
     per share, diluted:(1)

       Continuing operations                                          $(0.36)                             $2.02                 $(2.87)    $(0.49)

       Discontinued operations                                           0.01                             (0.44)                   0.10      (0.44)
                                                                         ----                              -----                    ----       -----

                                                                      $(0.35)                             $1.58                 $(2.77)    $(0.93)


    Shares used in calculating net loss
     attributable to stockholders of Arena per
     share, basic(1)                                                   39,268                             24,333                  32,990      24,313
                                                                       ======                             ======                  ======      ======

    Shares used in calculating net loss
     attributable to stockholders of Arena per
     share, diluted(1)                                                 39,268                             24,343                  32,990      24,313
                                                                       ======                             ======                  ======      ======

(1) Comparative period data
     adjusted to give effect to
     Arena's June 2017 1-for-10
     reverse stock split.

Arena Pharmaceuticals, Inc.

                         Condensed Consolidated Balance Sheet Data

                                       (In thousands)



                                  December 31, 2017                December 31, 2016
                                  -----------------                -----------------

                                                       1                               (1)

    Assets

       Cash
       &
       cash
       equivalents                              $158,837                           $90,712

       Accounts
       receivable                                  2,357                               573

       Insurance
       recovery
       receivable                                 12,025                                 -

       Prepaid
       expenses
       &
       other
       current
       assets                                      2,681                             2,169

       Total
       available
       for
       sale
       investments                               112,482                                 -

       Land,
       property
       &
       equipment,
       net                                        30,131                            35,109

       Other
       non-
       current
       assets                                      3,622                             2,841

       Total
       assets
       of
       disposal
       group
       held
       for
       sale                                       17,140                            37,606
                                                  ------                            ------

            Total
            assets                              $339,275                          $169,010
                                                ========                          ========


    Liabilities & Equity

       Accounts
       payable
       &
       accrued
       liabilities                               $15,622                            $9,559

       Accrued
       litigation
       settlement                                 24,000                                 -

       Total
       deferred
       revenues                                    2,177                             6,577

       Total
       lease
       financing
       obligations
       &
       other
       long-
       term
       liabilities                                62,737                            66,087

       Total
       liabilities
       of
       disposal
       group
       held
       for
       sale                                       27,595                            46,392

       Total
       equity                                    207,144                            40,395
                                                 -------                            ------

            Total
            liabilities
            &
            equity                              $339,275                          $169,010
                                                ========                          ========

(1) The Condensed Consolidated
     Balance Sheet Data has been
     derived from the audited
     financial statements as of that
     date.

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