Visterra to Present New Preclinical Data on VIS410 for Influenza A at the International Meeting on R

 Visterra, Inc. today announced that it will present new preclinical data on VIS410, a novel monoclonal antibody in development for treatment of hospitalized patients with influenza A, at the 2nd International Meeting on Respiratory Pathogens, at the Grand Copthorne Waterfront Hotel in Singapore, on March 7 - 9, 2018. The meeting is being conducted by the International Society for Influenza and Other Respiratory Virus Diseases (ISIRV).

Visterra is a clinical-stage biotechnology company that uses its novel Hierotope® platform to identify unique disease targets and to design and engineer precision antibody-based biological medicines against such targets that are not adequately addressed with conventional approaches.

The data presented demonstrate in vitro neutralizing activity by VIS410 against currently circulating seasonal influenza A, and binding and antiviral activity against newly emergent H7N9 strains, which are deadly avian influenza A strains that have infected humans. In addition, findings will be presented from two models based on data from the previously completed VIS410 human challenge study and published data. The first model describes serum concentrations of VIS410 observed in the VIS410 human challenge study and its impact on viral load. The second model predicts clinical efficacy of VIS410 at doses under study by Visterra for treatment of hospitalized influenza A patients, in combination with oseltamivir.

"We look forward to participating in this important conference and sharing these new and encouraging in vitro data of VIS410 binding and antiviral activity against newly emergent H7N9 strains. While great strides have been made in China in curtailing the current wave of human H7N9 infections, this virus and other emergent avian influenza A strains continue to present ongoing pandemic potential of grave concern," said David Oldach, MD, Chief Medical Officer of Visterra. "The modeling data indicate the potential for VIS410 efficacy at doses currently under evaluation. We continue to advance VIS410 in the clinic and are conducting a Phase 2b global clinical trial of VIS410 in combination with oseltamivir versus oseltamivir alone in hospitalized patients with influenza A."

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