T&W Group - Process Chemistry Expert

T&W Group- Process Chemistry Expert

Headquartered in Shanghai, China, with production sites in Shandong and Jiangsu, T&W Group is providing scale-up synthesis, process development and manufacturing of key intermediates/RSMs serving the pharmaceuticals, agrochemicals and performance chemicals areas. （www.trustwe.com）

Key Technologies

• Selective Hydrogenation Reactions

  With expertise in catalyst designing and screening to achieve optimized selectivity.

  Rich experience in continuous hydrogenation in tubular reactors.

  Maximal pressure can reach 3.5MPa, 500L-3000L batch autoclaves are available.

   

• Preparation of Chiral compounds

  Specialized in enzymatic method.

   

• High-vacuum Rectification 

  Vacuum can reach 5-20Pa with two stage vacuum roots pump;

   Oil temperature can reach 300℃.

   

• Low-temperature and High-temperature Reaction

  Low temperature can reach -78℃.

  High temperature can reach 300℃.

   

• Grignard Reaction

  Rich experience in Grignard operation, by using up to 5000L reactors with DCS and ESD automatic control system.

   

• Halogenating Reaction

  Full advantage of using Chlorine and bromide.

   

• Sulfo-compounds

  Tested solutions to keep high EHS standard.

   

• Hazardous Chemistry

  Credential of using NaCN etc.

Products and Markets

• Pharma Intermediates Case: 1-Bromo-2-butyne

• A completely innovative route, which made 2/3 cost off compare to other suppliers.

• It is an unstable key intermediate, needs high vacuum distillation, needs to have a comprehensive EHS solution.

• Our standard is improved greatly to: Purity > 99.0%, known impurities: <0.3%, Unknown impurities: <0.1%. And we are the principal supplier globally. 

   

• Specialty Chemical Case: Special Catalyst

• Readily soluble in organic solvents, free of any metal component.

• Has basicity similar to the hydroxide of an alkali metal or alkaline metals.

• high recovery rate, challenging chemistry, difficult in structure identification (no reference).

Custom Manufacturing

Your chemistry partner for research & development

Process development and optimization are core competencies at T&W. Our company has a dedicated staff of professional process chemists and engineers with substantial experience and expertise in the development of robust chemical processes.

• Chemical development capabilities include:

  De-novo development of chemical processes

  Process research, development and optimization

  Resolution of challenging process bottlenecks

  Laboratory and pilot process scale-up to plant-size equipment

  Process safety / hazard assessment

  Dedicated analytical process support

  QbD process development

  Typical process enhancement includes:

  Improved yields

  Reduction in the number of steps and operations

  Reduction in volume

  Elimination of chromatography

  Ease of scalability

  Safe and robust processes

  Mitigation of negative environmental impacts

  Cost optimization

  
  

  Your Reliable Partner

   

• In-depth process knowledge and "know-how", excellent project management skills.

• Innovation-driven process research, development and production capability.

• Extensive international cooperation experience.

• Well established IP protection system.