biospectrumasiaOctober 09, 2017
Tag: Breast Cancer , DNA
Researchers in Singapore and their international partners from Denmark and USA, have successfully discovered a unique biomarker that is strongly linked with breast cancer relapse. This finding has paved the way for the development of a simple blood test which has many clinical applications, such as detecting recurrence early and testing treatment efficacy.
The study was recently published in scientific journal Nature Medicine in September 2017.
Jointly led by A*STAR’s Genome Institute of Singapore (GIS), Tan Tock Seng Hospital (TTSH) and National University Health System (NUHS), the research utilised an integrative genomic approach to analyse tumour samples from breast cancer patients, which led to the identification of this biomarker. The identified biomarker was found in more than 70% of recurrent tumours, taken from breast cancer patients who suffered relapse of the disease.
In addition, the study shows that early stage patients whose tumours tested positive for this biomarker at the time of diagnosis are nearly 40 times more likely to develop a relapse within 5 years than patients whose tumours tested negative. The finding prompted GIS Innovation Fellow Dr Goh Jian Yuan and his colleagues to develop a blood-based diagnostic test kit to detect tumour DNA in the blood. "Tumour relapse remains the main reason for breast cancer mortality. However, there are unmet clinical demands for new technology to monitor patients or treatment to prevent disease relapse.
The blood test we developed based on this finding can be potentially used to monitor tumour progression after treatment so that doctors can make early decisions on other forms of therapy," explained the study’s lead author Prof Yu Qiang, Senior Group Leader, Cancer Therapeutics & Stratified Oncology at GIS. "A finding like this has strong clinical potential; it warrants further prospective clinical validations and future commercial development," he added.
Breast cancer is the most common cancer in women in the world. It is estimated that over 508,000 women died of breast cancer in 2011.
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