biospectrumasiaJuly 04, 2017
Tag: Amgen , cholesterol , singapore
Amgen, a US based biotechnology company, announced the availability of Repatha(evolocumab), the first PCSK9 inhibitor for lowering high cholesterol, in Singapore.
Repatha is a new class of drugs called proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitors. It is a fully human monoclonal antibody that inhibits PCSK9 from binding to low-density lipoprotein (LDL) receptors. In the liver, this interaction enables our bodies to have more LDL receptors available to remove low-density lipoprotein cholesterol (LDL-C), or "bad" cholesterol, from the blood.
Elevated LDL-C is recognized as a major risk factor for cardiovascular disease (CVD). CVDs, such as heart disease and stroke, are Singapore’s leading cause of death, accounting for 1 in every 3 deaths in 2015. CVDs also result in steep direct and indirect costs for patients. The average medical cost for an acute stroke is over S$22,000, which is the equivalent of almost two months of an average Singaporean family’s income.
"While available treatments for other diseases are advancing in leaps and bounds, there hasn’t been much movement to address high cholesterol since the development of statin therapy in the late 1980s," said Dr. Peter Yan Chee Hong, Consultant Cardiologist at Gleneagles Medical Centre. "Repatha provides a new treatment option for patients who experience side effects while on statin therapy or remain unable to control their cholesterol levels."
Data from clinical trials demonstrated that Repatha resulted in up to 77% additional LDL-C reduction in patients receiving background statin therapy. "This is the first significant innovation in 30 years for cholesterol management, and we look forward to seeing how it will impact patient lives and help combat the rising burden of CVD," said Raphael Ho, General Manager of Amgen Singapore.
Approved by the Health Sciences Authority, the cholesterol-lowering drug Repatha is indicated for:
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