An improved tool to detect cancer

In a collaborative research project, scientists from Griffith University's Institute for Glycomics, the University of Adelaide and University of Queensland have discovered a new and improved tool to detect cancer.

The researchers took a naturally occurring E. coli toxin that recognizes a tumor antigen, and engineered it to change the protein make-up so it became entirely specific to detecting only this singular tumor antigen structure.

The real innovation here is that the researchers have converted something that was discovered in an infectious disease research program into food poisoning and were able to utilize it as a tool for potentially detecting tumor antigens.

The substance Neu5Gc recognized by the E.coli toxin is expressed at very high levels on cancer cells but not normal cells so the discovery of Neu5Gc indicates the patient may be suffering cancer.

Humans are unable to make Neu5Gc but is absorbed into the human body through dietary intake of red meat and dairy.

More research has to be done but the important thing is this new tool has the potential to detect far more sensitively, a wide range of possible cancers.