Company Profile of JenKem Technology Co., Ltd.

　　Founded in 2001 by experts in PEG synthesis and PEGylation, JenKem Technology specializes in high-purity, low polydispersity polyethylene glycol (PEG) derivatives, PEG co-polymers, monodisperse PEGs, custom PEG derivative synthesis and PEGylation services. Specific strengths are supported by access to bulk ethylene oxide and the performance of all polymerizations and derivatizations in-house.

　　JenKem Technology supplies PEG derivatives worldwide, from R&D through GMP commercial quantities, for preclinical, clinical trials, and commercial products for pharma, biotech, medical devices, and diagnostics.

　　Capabilities

　　Development and manufacture of a wide range of PEG and PEG co-polymer derivatives with high purity and low polydispersity, currently in 1 gram to 40 kg or greater sized batches, under ISO 9001 and ISO 13485 certified Quality Management Systems, following ICH Q7 guidelines for GMP manufacture.

　　Controlled manufacture of raw polyethylene glycol polymers with targeted molecular weights and functionality via the polymerization of ethylene oxide in 5kg, 15kg, 20kg, and 100kg batches, as needed, for PEG derivative manufacture, with annual capacity of over 10 metric tons of high quality raw PEGs, with a new plant that has come on stream in 2017 which also has the capability of the purification of these raw PEGs under GMP conditions if needed for even higher quality products.

　　Custom synthesis of activated and raw PEGs: Y-Shaped, Linear Methoxy, Homobifunctional, Heterobifunctional, Multi-arm and Multi-arm Heterobifunctional, Monodisperse (Discrete) PEGs, Biodegradable PEG Co-Polymers such as PEG-PLGA, PEG-PLA, PEG-PCL, and other block co-polymers, and PEG GPC Standards.

　　Custom PEGylation of proteins, peptides, oligonucleotides, and small molecules; and conjugation of PEGs to other polymer systems.

　　Online ordering of JenKem® catalog PEG products available on our website, with global distribution of JenKem® PEG products direct from JenKem Technology China facilities. Many research grade PEG derivatives sold through a collaboration with MilliporeSigma, listed in their catalog and on their website and identified as being a product of JenKem Technology. Large scale and GMP manufacturing offered on a custom synthesis basis, with flexibility to match customers’ specifications.

　　Intellectual Property

　　JenKem Technology respects the intellectual property of others

　　As of August 2021, JenKem Technology has 86 patent approvals, 43 pending patent applications, and many other novel technologies under development

　　Several innovative PEG and PEGylation-related technologies patented by JenKem Technology are available for out-licensing

　　JenKem Technology has filed DMFs for several of its PEG products, and has the capability to file other DMFs with the US FDA and China FDA at customers’ request

　　Locations

　　JenKem Technology Tianjin – Site for commercial scale GMP manufacture of PEG derivatives, small scale PEG production, and R&D

　　New plant in Tianjin, China, came on stream in 2013

　　Audited by numerous multi-national pharma, biotech, and medical device companies for commercial-scale PEG manufacture

　　Located in the established Tianjin Economic-Technological Development Area (TEDA), a thriving area with globally recognized companies

　　Neighbors include: GSK, Novo Nordisk, Wuxi, and Novozymes

　　JenKem Technology Liaoning – Facility for PEG raw materials manufacture and back-up GMP manufacture of PEG derivatives

　　Newest plant in Panjin, China, came on stream in 2017

　　Located in the Liaoning province

　　Convenient access to ethylene oxide raw material for PEG raw material production

　　Back-up facility for GMP production

　　JenKem Technology Beijing – Headquarters, R&D, PEGylation site

　　Located in New Northwest Territories Development Zone, Beijing, China

　　Part of Zhongguancun Science Park

　　Surrounded by numerous international companies

　　Sales and marketing for JenKem Technology’s customers located in mainland China

　　JenKem Technology USA – JenKem Technology’s international business office

　　Sales, business development, technical support, and marketing for JenKem Technology’s PEG and PEG co-polymer products, custom PEG synthesis, and PEGylation services

　　Serves all JenKem Technology’s customers located outside mainland China

　　Located in the Dallas, TX area