June 24, 2021
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When it comes to S-LYSOPC, some friends may not be so familiar with it. From its product name, you can know that it is a lysophospholipid. It has many roles and effects and can be used in many places. In this issue of AVT Editor, a simple description of S-LYSOPC medical excipients, interested partners to learn about it!
What kind of lysophosphatidylstearyl lysophosphatidyl-S-LYSOPC is?
| Chinese name: 1 - stearoyl - hemolysis phosphatidyl choline
| alias: stearyl lysolecithin
| chemical name: 1 - stearoyl - sn - glycerol - 3 - choline phosphate
| English name: S - LysoPC
| registration number: F20170000006
| levels: medicinal injection level
| the CAS no. : 19420-57-6
| DMF number: 25330
| molecular formula: C26H54NO7P
| molecular weight: 523.68
Application: | adriamycin liposome win min
Learn about doxorubicin thermosensitive liposomes
The LTSL (lysolipid thermally sensitive liposome) technology, developed by Duke University, USA, was awarded an exclusive JIA license for the project and LTSL technology by Celsion in 1999. The advantage of LTSL technology is the ability to deliver high concentrations of drugs -- up to 25 times the systemic dose -- at a targeted location through appropriate temperature increases. In addition to doxorubicin, LTSL technology has also been used in the delivery of some other small molecule anti-AI drugs, such as docetaxel and carboplatin.
Adriamycin liposome win min it is through intelligent transportation adriamycin LTSL technologies: drugs will not release under normal temperature, and through radiofrequency ablation (RFA) technology, infrared heating methods such as elevated temperature to 42 ° C liver after a period of time, doxorubicin in the liver gradually released, this will be a high dose of adriamycin to liver ai organization directly. China is a major country of liver AI, accounting for more than half of the cases in the world, and the number of cases is increasing rapidly at the rate of 400,000 to 500,000 annually. If this product can go on the market smoothly, the market prospect will be very huge.
The phospholipid components of adriamycin thermosensitive liposomes included DPPC, S-LYSOPC and DSPE-MPEG2000, and the molar ratio was 86:9.5:4.5.
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